Joles J A, Nicaise E, Sanders M, Schot A
Int J Sports Med. 1984 Dec;5(6):306-10. doi: 10.1055/s-2008-1025922.
The albuminuria occurring after swimming in splenectomized dogs was investigated. Swimming in splenectomized dogs induces metabolic acidosis, a decrease in renal vascular conductance, and an increase in plasma renin activity, all three factors possibly implicated in the occurrence of albuminuria. The administration of sodium bicarbonate prior to swimming reduced the magnitude of the acidosis and eliminated the increase in albuminuria after swimming. Phenoxybenzamine, an alpha-adrenergic blocking agent that maintains the renal blood flow during exercise also blocked the increase in albuminuria despite a decrease of blood pH during swimming. However, after metoprolol, a beta 1-adrenergic blocking agent that blocks the rise in plasma renin activity during exercise, swimming causes a threefold increase in albuminuria (P less than 0.01). The albuminuric response to swimming preceded by saline was also significant (P less than 0.05). It is likely that post-swimming albuminuria in splenectomized dogs is linked to the decrease of renal vascular conductance or to the decrease in blood pH rather than to the rise in plasma renin activity.
对脾切除术后的犬类游泳后出现的蛋白尿进行了研究。脾切除术后的犬类游泳会引发代谢性酸中毒、肾血管传导性降低以及血浆肾素活性增加，这三个因素都可能与蛋白尿的发生有关。游泳前给予碳酸氢钠可减轻酸中毒的程度，并消除游泳后蛋白尿的增加。苯氧苄胺是一种α-肾上腺素能阻滞剂，可在运动期间维持肾血流量，尽管游泳期间血液pH值下降，但它也能阻止蛋白尿的增加。然而，美托洛尔是一种β1-肾上腺素能阻滞剂，可阻止运动期间血浆肾素活性的升高，游泳后蛋白尿会增加三倍（P<0.01）。盐水预处理后对游泳的蛋白尿反应也很显著（P<0.05）。脾切除术后犬类游泳后蛋白尿可能与肾血管传导性降低或血液pH值下降有关，而非与血浆肾素活性升高有关。
