Matteri R L, Watson J G, Moberg G P
J Reprod Fertil. 1984 Nov;72(2):385-93. doi: 10.1530/jrf.0.0720385.
This study examined the effects of varying treatment durations and doses of adrenocorticotrophin (ACTH) as well as restraint stress on the LH response to exogenous LHRH. Injection of 80 i.u. of a concentrated ACTH preparation at 11, 6, 3 or 1.5 h before LHRH administration was effective in suppressing the LH response. Injection of 40, but not 20 or 10, i.u. ACTH 3 h before an LHRH challenge inhibited the magnitude of the LH response, while cortisol values did not vary between ACTH doses. Injection of 200 micrograms of synthetic ACTH1-24 also resulted in a reduced LH response when given 3 h before LHRH. Restraint stress caused elevated corticosteroid levels and reduced LHRH responsiveness. The results of this study suggest that stress may cause an inhibition of pituitary gland ability to respond to LHRH by way of an hormonal component of the adrenocortical axis. A glucocorticoid-independent mechanism may be involved.
本研究考察了不同治疗时长、促肾上腺皮质激素（ACTH）剂量以及束缚应激对促黄体生成素（LH）对外源性促性腺激素释放激素（LHRH）反应的影响。在给予LHRH前11、6、3或1.5小时注射80国际单位浓缩ACTH制剂可有效抑制LH反应。在LHRH激发前3小时注射40国际单位ACTH（而非20或10国际单位）可抑制LH反应的幅度，而不同ACTH剂量组的皮质醇值无差异。在LHRH前3小时给予200微克合成ACTH1 - 24也会导致LH反应降低。束缚应激导致皮质类固醇水平升高且LHRH反应性降低。本研究结果表明，应激可能通过肾上腺皮质轴的激素成分抑制垂体对LHRH的反应能力。可能涉及一种不依赖糖皮质激素的机制。
