Nishindai H, Nakanishi M, Kasai Y, Hashimoto I, Sawada Y, Nakamura T, Fugono T, Maeda K
Jpn J Antibiot. 1983 Dec;36(12):3412-21.
Concentrations of cefotiam (CTM) in the exudate after abdominal operation were studied. The exudates were collected by 6 mm paper discs and the antibiotic concentrations were determined by the paper disc method using Proteus rettgeri ATCC 9250 as test organism. Comparison between agar well and paper disc assay for CTM in ascites specimens showed good correlation. Two grams of CTM was intravenously given to the patients after abdominal operations. The concentration of CTM in the exudate for 6 hours after injection was 0.4--14.2 micrograms/ml and this value exceeded the antibacterial level of CTM. It is, therefore, concluded that CTM will be effective for the postoperative prophylaxis.
对腹部手术后渗出液中头孢替安（CTM）的浓度进行了研究。通过6毫米纸盘收集渗出液，并使用雷氏普罗威登斯菌ATCC 9250作为测试菌株，采用纸盘法测定抗生素浓度。对腹水标本中CTM的琼脂孔法和纸盘法测定结果进行比较，显示出良好的相关性。腹部手术后给患者静脉注射2克CTM。注射后6小时渗出液中CTM的浓度为0.4--14.2微克/毫升，该值超过了CTM的抗菌水平。因此，得出结论，CTM对术后预防有效。
