Kudo T, Baird A
Nature. 1984;312(5996):756-7. doi: 10.1038/312756a0.
Several forms of the polypeptide atrial natriuretic factor (ANF) have been isolated recently from rat and human atria and identified; they are probably associated with the secretory granules of atrial tissue. The potent ability of ANFs to increase urine sodium content is mediated by their direct action on the kidney. We report here the high intrinsic activity of a synthetic replicate of one form of this molecule, ANF(8-33)(ref. 7), to inhibit directly basal aldosterone secretion and its ability to antagonize the stimulatory effects of adrenocorticotropin (ACTH) and angiotensin II (AN-II) on the secretion of aldosterone by rat adrenoglomerulosa cells in vitro. Our results suggest that ANF is of clinical importance in the management of aldosterone-dependent hypertension by modifying the adrenocortical response to endogenous ACTH and AN-II.
最近已从大鼠和人的心房中分离并鉴定出几种形式的多肽心房利钠因子（ANF）；它们可能与心房组织的分泌颗粒有关。ANF增加尿钠含量的强大能力是通过其对肾脏的直接作用介导的。我们在此报告这种分子的一种形式ANF(8 - 33)（参考文献7）的合成复制品具有高内在活性，可直接抑制基础醛固酮分泌，并且能够在体外拮抗促肾上腺皮质激素（ACTH）和血管紧张素II（AN-II）对大鼠肾上腺球状带细胞醛固酮分泌的刺激作用。我们的结果表明，ANF通过改变肾上腺皮质对内源性ACTH和AN-II的反应，在醛固酮依赖性高血压的管理中具有临床重要性。
