Heppleston A G, Kulonen E, Potila M
Am J Ind Med. 1984;6(5):373-86. doi: 10.1002/ajim.4700060507.
Relying on in vitro production of the macrophage fibrogenic factor, an attempt was made to quantitate the fibrogenicity of mineral particles. Having determined the optimal conditions by means of quartz, two series of experiments were conducted with respirable coal mine dusts; the first employed artificial mixtures of a mine dust, having a low natural quartz content, with various proportions of quartz, and the second native dusts from European mines. The fibrogenic responses in both series suggest that dust concentration is more important than its composition. Quartz and ash contents of native dusts bore no evident relation to fibrogenicity, high quartz and ash levels sometimes being associated with low collagen levels and vice versa. Comparison with other information disclosed disparities with epidemiology and different experimental assessments. Factors affecting the disarray may well include the neglected lipid response in vivo and individual susceptibility, aspects which do not appear beyond experimental assay.
依靠巨噬细胞纤维生成因子的体外产生，人们尝试对矿物颗粒的纤维生成能力进行定量。通过石英确定了最佳条件后，对可吸入煤矿粉尘进行了两个系列的实验；第一个实验使用了天然石英含量低的煤矿粉尘与不同比例石英的人工混合物，第二个实验使用了欧洲煤矿的天然粉尘。两个系列的纤维生成反应表明，粉尘浓度比其成分更重要。天然粉尘中的石英和灰分含量与纤维生成能力没有明显关系，高石英和灰分水平有时与低胶原蛋白水平相关，反之亦然。与其他信息的比较揭示了与流行病学和不同实验评估的差异。影响这种混乱的因素很可能包括体内被忽视的脂质反应和个体易感性，而这些方面在实验分析之外似乎并不明显。
