环磷酸腺苷（cAMP）对人中性粒细胞中fMet-Leu-Phe依赖性代谢反应的抑制作用并非源于其对胞质Ca2+的影响。
Cyclic AMP inhibition of fMet-Leu-Phe-dependent metabolic responses in human neutrophils is not due to its effects on cytosolic Ca2+.
作者信息
De Togni P, Cabrini G, Di Virgilio F
出版信息
Biochem J. 1984 Dec 1;224(2):629-35. doi: 10.1042/bj2240629.
Abstract
Cyclic AMP powerfully inhibits the fMet-Leu-Phe-dependent respiratory burst and exocytosis of azurophilic and specific granules without affecting Ca2+ release from intracellular stores. The elevation of [Ca2+]i induced by fMet-Leu-Phe is short-lived in cyclic AMP-treated cells and similar to that of untreated cells stimulated in the absence of external Ca2+. Nevertheless, in these latter cells fMet-Leu-Phe induces metabolic activation. We therefore suggest that the inhibitory action of cyclic AMP on neutrophil responses is not due to its effects on [Ca2+]i homoeostasis.
摘要
环磷酸腺苷（cAMP）强烈抑制甲酰甲硫氨酸-亮氨酸-苯丙氨酸（fMet-Leu-Phe）依赖的呼吸爆发以及嗜天青颗粒和特异性颗粒的胞吐作用，而不影响细胞内钙库的钙离子释放。在经cAMP处理的细胞中，fMet-Leu-Phe诱导的细胞内钙离子浓度（[Ca2+]i）升高是短暂的，且与在无细胞外钙离子刺激的情况下未处理细胞的情况相似。然而，在这些后者的细胞中，fMet-Leu-Phe会诱导代谢激活。因此，我们认为cAMP对中性粒细胞反应的抑制作用并非因其对[Ca2+]i稳态的影响。
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