Campello C, Dal Molin G, Gasparini V, Mestroni L, Salvi A, Camerini F, Majori L
Boll Ist Sieroter Milan. 1984 Sep;63(4):325-30.
Thirty patients with congestive cardiomyopathy (C.C.) have been studied for the prevalence of neutralizing antibodies to coxsackie B viruses in comparison with age and sex matched controls. Seropositivity toward each antigen was similar in cases and controls: an exception was coxsackie B5 virus, where a significantly seropositivity was found in the control group. As a whole, high antibody titers to any antigen were observed more frequently on sera of cardiopathic patients; however the difference between cases and controls of g.m.t. to each antigen tested was not statistically significant, with the exception of coxsackie B1 virus. The absence of a clear relationship between C.C. and viral infections might be explained through biological as well as epidemiological considerations; of particular relevance, the long duration of cardiac disease (average length 71 months, median 54). Final considerations are offered regarding the methodologic approach for a better understanding of the etiology of this elusive disease.
对30例充血性心肌病（C.C.）患者进行了研究，以比较其与年龄和性别匹配的对照组中柯萨奇B病毒中和抗体的流行情况。病例组和对照组对每种抗原的血清阳性率相似：柯萨奇B5病毒是个例外，在对照组中发现其血清阳性率显著升高。总体而言，在心脏病患者的血清中更频繁地观察到对任何抗原的高抗体滴度；然而，除柯萨奇B1病毒外，病例组和对照组对每种测试抗原的几何平均滴度差异无统计学意义。C.C.与病毒感染之间缺乏明确关系可能可以通过生物学和流行病学因素来解释；特别相关的是，心脏病的病程较长（平均时长71个月，中位数54个月）。最后就更好地理解这种难以捉摸的疾病病因的方法学途径提出了一些思考。
