Somerfield S D, Stach J L, Mraz C, Gervais F, Skamene E
Inflammation. 1984 Dec;8(4):385-91. doi: 10.1007/BF00918214.
Investigation of the antiinflammatory properties of bee venom demonstrates that it inhibits production of superoxide anion by human neutrophils in a potent, selective, nontoxic, dose-dependent fashion, both pre- and poststimulation by particulate and soluble activators of the neutrophil oxidative metabolism burst. The effect is not due to receptor competition, superoxide dismutase, and/or catalase activity, scavenging, or indicator media effects. These findings may explain the antiinflammatory effects of whole bee venom in experimental systems, its widespread use in folk medicine, and lead to the development of potent, new antiinflammatory substances for therapeutic use in man.
对蜂毒抗炎特性的研究表明，它能以有效、选择性、无毒且剂量依赖的方式抑制人类中性粒细胞产生超氧阴离子，无论是在中性粒细胞氧化代谢爆发的颗粒性和可溶性激活剂刺激前还是刺激后。这种作用并非由于受体竞争、超氧化物歧化酶和/或过氧化氢酶活性、清除作用或指示剂介质效应。这些发现可能解释了全蜂毒在实验系统中的抗炎作用、其在民间医学中的广泛应用，并可能促使开发出用于人类治疗的强效新型抗炎物质。
