HLA II类SB轻链基因的结构与多态性
Structure and polymorphism of the HLA class II SB light chain genes.
作者信息
Kappes D J, Arnot D, Okada K, Strominger J L
出版信息
EMBO J. 1984 Dec 1;3(12):2985-93. doi: 10.1002/j.1460-2075.1984.tb02245.x.
Abstract
The HLA Class II region contains at least three groups of loci, DR, DC and SB, which play an important role in the immune response. The antigens encoded at these loci are heterodimers composed of an alpha and a beta chain. The sequence of a complete Class II beta cDNA clone whose sequence agrees closely with the limited N-terminal protein sequence available for the SB beta chain is reported. In addition the structure and coding sequence of genomic SB beta clones of two different SB haplotypes has been obtained and allows definition of some polymorphic regions. The SB beta gene appears to undergo alternate splicing at its 3' end, resulting in expression of two different intracytoplasmic regions. Partial sequencing of a second non-allelic SB beta-like gene, SX beta, indicates that it is a pseudogene.
摘要
HLA II类区域至少包含三组基因座，即DR、DC和SB，它们在免疫反应中起重要作用。这些基因座编码的抗原是由一条α链和一条β链组成的异二聚体。本文报道了一个完整的II类β cDNA克隆的序列，该序列与SBβ链可获得的有限N端蛋白质序列高度一致。此外，还获得了两种不同SB单倍型的基因组SBβ克隆的结构和编码序列，并确定了一些多态性区域。SBβ基因似乎在其3'端发生可变剪接，导致两种不同的胞质内区域的表达。对第二个非等位SBβ样基因SXβ的部分测序表明它是一个假基因。
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本文引用的文献
1
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EMBO J. 1983;2(3):389-94. doi: 10.1002/j.1460-2075.1983.tb01435.x.
2
Family studies define a new histocompatibility locus, SB, between HLA-DR and GLO.家系研究在HLA - DR和GLO之间确定了一个新的组织相容性位点SB。
Nature. 1981 Oct 29;293(5835):745-7. doi: 10.1038/293745a0.
3
Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens.根据核苷酸序列预测的一种HLA - DR抗原样β链的完整氨基酸序列：与免疫球蛋白以及HLA - A、- B和 - C抗原的相似性。
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3687-91. doi: 10.1073/pnas.79.12.3687.
4
Mutations and selection in the generation of class II histocompatibility antigen polymorphism.II类组织相容性抗原多态性产生过程中的突变与选择
EMBO J. 1984 Jul;3(7):1655-61. doi: 10.1002/j.1460-2075.1984.tb02026.x.
5
Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.人类Ⅱ类组织相容性抗原α链基因的同种型和异型变异
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6
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9
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