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Genetic mapping of a human class II antigen beta-chain cDNA clone to the SB region of the HLA complex.人类Ⅱ类抗原β链cDNA克隆的基因定位至HLA复合体的SB区域。
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Major histocompatibility complex gene organization in the mole rat Spalax ehrenbergi: evidence for transfer of function between class II genes.东非鼹形鼠（Spalax ehrenbergi）的主要组织相容性复合体基因组织：II类基因间功能转移的证据
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Complete sequence of an HLA-dR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes.从一个cDNA克隆推导的HLA - dRβ链的完整序列以及多个非等位DRβ链基因的鉴定。
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7
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Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB beta-chain genes.人类主要组织相容性复合体HLA - SB区域的分子组织及两个SBβ链基因的证据
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HLA II类SB轻链基因的结构与多态性

Structure and polymorphism of the HLA class II SB light chain genes.

作者信息

Kappes D J, Arnot D, Okada K, Strominger J L

出版信息

EMBO J. 1984 Dec 1;3(12):2985-93. doi: 10.1002/j.1460-2075.1984.tb02245.x.

DOI:10.1002/j.1460-2075.1984.tb02245.x
PMID:6098459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC557802/
Abstract

The HLA Class II region contains at least three groups of loci, DR, DC and SB, which play an important role in the immune response. The antigens encoded at these loci are heterodimers composed of an alpha and a beta chain. The sequence of a complete Class II beta cDNA clone whose sequence agrees closely with the limited N-terminal protein sequence available for the SB beta chain is reported. In addition the structure and coding sequence of genomic SB beta clones of two different SB haplotypes has been obtained and allows definition of some polymorphic regions. The SB beta gene appears to undergo alternate splicing at its 3' end, resulting in expression of two different intracytoplasmic regions. Partial sequencing of a second non-allelic SB beta-like gene, SX beta, indicates that it is a pseudogene.

摘要

HLA II类区域至少包含三组基因座，即DR、DC和SB，它们在免疫反应中起重要作用。这些基因座编码的抗原是由一条α链和一条β链组成的异二聚体。本文报道了一个完整的II类β cDNA克隆的序列，该序列与SBβ链可获得的有限N端蛋白质序列高度一致。此外，还获得了两种不同SB单倍型的基因组SBβ克隆的结构和编码序列，并确定了一些多态性区域。SBβ基因似乎在其3'端发生可变剪接，导致两种不同的胞质内区域的表达。对第二个非等位SBβ样基因SXβ的部分测序表明它是一个假基因。