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小鼠主要组织相容性复合体中高或低序列差异的区域

Tracts of high or low sequence divergence in the mouse major histocompatibility complex.

作者信息

Steinmetz M, Malissen M, Hood L, Orn A, Maki R A, Dastoornikoo G R, Stephan D, Gibb E, Romaniuk R

出版信息

EMBO J. 1984 Dec 1;3(12):2995-3003. doi: 10.1002/j.1460-2075.1984.tb02246.x.

DOI:10.1002/j.1460-2075.1984.tb02246.x
PMID:6098460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC557803/
Abstract

The K, I and S regions of the mouse major histocompatibility complex (MHC) are composed of long tracts of DNA which differ in sequence divergence. A correlation exists between the location of an MHC gene in a variable or conserved chromosomal tract and the degree of polymorphism and diversity of the proteins encoded by its alleles. Variable tracts appear to be the result of mechanisms which mutate certain coding and non-coding sequences to the same extent and selective pressures operating on the genes.

摘要

小鼠主要组织相容性复合体（MHC）的K、I和S区域由序列差异不同的长段DNA组成。MHC基因在可变或保守染色体区域中的位置与其等位基因编码的蛋白质的多态性和多样性程度之间存在相关性。可变区域似乎是某些编码和非编码序列以相同程度发生突变的机制以及作用于这些基因的选择压力的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c44a/557803/93fa7a8757fd/emboj00316-0269-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c44a/557803/93fa7a8757fd/emboj00316-0269-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c44a/557803/93fa7a8757fd/emboj00316-0269-a.jpg

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本文引用的文献

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Immunochemical evidence in two haplotypes for at least three D region-encoded molecules, D, L, and R.
包含H2-M和Lmp2基因座的小鼠MHC II类区域的基因组组织。
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