Williams R C
Int J Environ Anal Chem. 1984;18(1-2):37-49. doi: 10.1080/03067318408076990.
The Du Pont PREP automated sample processor is a centrifugally based, microprocessor controlled instrument that was designed for extraction of samples from biological fluids. Extraction takes place in cartridges containing either organic resins or bonded silica packings as extraction sorbants. This paper will discuss the application of several lipophilic and ion exchange sorbants to the extraction of biological samples from body fluids. The advantages of these different types of sorbants will be compared and their performance with automated sample preparation will be shown. A variety of applications including the extraction of benzodiazepine, barbiturate, aminoglycoside and anticonvulsant drugs and their metabolites from serum, urine, and tissue homogenates will be discussed.
杜邦PREP自动样品处理器是一种基于离心原理、由微处理器控制的仪器，设计用于从生物流体中提取样品。提取过程在装有有机树脂或键合硅胶填料作为提取吸附剂的小柱中进行。本文将讨论几种亲脂性和离子交换吸附剂在从体液中提取生物样品方面的应用。将比较这些不同类型吸附剂的优点，并展示它们在自动样品制备中的性能。还将讨论各种应用，包括从血清、尿液和组织匀浆中提取苯二氮卓类、巴比妥类、氨基糖苷类和抗惊厥药物及其代谢物。
