Salvioni R, Faustini M, Piva L, Pasi M, Pizzocaro G
Chemioterapia. 1984 Aug;3(4):223-6.
In cis-platinum treatment, nausea and vomiting are very serious side-effects and patients may be reluctant to accept or continue therapy. The purpose of this study is to verify the antiemetic effect of methylprednisolone in patients treated with cis-platinum in combination with other chemotherapeutic agents. Methylprednisolone in doses of 100 mg/m2 i.v. per 5 consecutive days was given to 33 patients receiving cis-platinum combination chemotherapies (134 cycles) at the Istituto Nazionale Tumori of Milan for advanced germ cell tumors of the testis. Seventy percent of cycles were partially or completely protected from vomiting. Only minor side-effects caused by methylprednisolone were observed. From this study it appears that methylprednisolone is an effective antiemetic drug in patients receiving cis-platinum combination chemotherapy.
在顺铂治疗中，恶心和呕吐是非常严重的副作用，患者可能不愿接受或继续治疗。本研究的目的是验证甲泼尼龙对接受顺铂联合其他化疗药物治疗的患者的止吐效果。在米兰国家肿瘤研究所，对33例接受顺铂联合化疗（134个疗程）治疗晚期睾丸生殖细胞肿瘤的患者，连续5天静脉注射剂量为100mg/m²的甲泼尼龙。70%的疗程呕吐得到部分或完全缓解。仅观察到甲泼尼龙引起的轻微副作用。从这项研究来看，甲泼尼龙对接受顺铂联合化疗的患者是一种有效的止吐药物。
