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大麻、阿托品与时间信息处理

Cannabis, atropine, and temporal information processing.

作者信息

Hicks R E, Gualtieri C T, Mayo J P, Perez-Reyes M

出版信息

Neuropsychobiology. 1984;12(4):229-37. doi: 10.1159/000118144.

DOI:10.1159/000118144
PMID:6100128
Abstract

In experiment 1, subjects judged time by duration production under no-counting instructions. The productions were made following intravenous injection of atropine sulfate or saline, and after smoking cigarettes with and without (-)-delta 9-tetrahydrocannabinol (THC). THC increased the subjective time rate (STR); i.e., the rate at which subjective time passes relative to clock time, whereas atropine had no effect on STR. Thus, reduction in central acetylcholine activity is not a sufficient explanation of THC's effect on STR. Experiment 2 replicated the THC effect on STR when subjects were counting subjective seconds. This result indicates that THC affects the experience of time as it is passing, and not solely the memory for duration experience after a time period.

摘要

在实验1中,受试者在不计数指令下通过时长生成来判断时间。在静脉注射硫酸阿托品或生理盐水后,以及吸食含和不含(-)-δ9-四氢大麻酚(THC)的香烟后进行时长生成。THC增加了主观时间率(STR);即主观时间相对于时钟时间流逝的速率,而阿托品对STR没有影响。因此,中枢乙酰胆碱活性的降低并不能充分解释THC对STR的影响。实验2在受试者计数主观秒数时重复了THC对STR的影响。这一结果表明,THC影响时间流逝时的时间体验,而不仅仅是一段时间后对时长体验的记忆。

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