[Fibrin fibrinogen degradation products in the cerebrospinal fluid of neurological patients].

The authors determined FDP levels in the cerebrospinal fluid by the method of Merskey in 214 neurological patients and found raised levels in 58.6% of cases (from 0.1 to 8.0 ug/ml, with normal value range 0-0.5 ug/ml). In the control group the FDP levels in the CSF were normal. No correlation was noted between the FDP levels in the CSF and in blood. Raised CSF FDP level was observed in exacerbations of multiple sclerosis, strokes especially of embolic origin, syringomyelia, bulbar form of amyotrophic lateral sclerosis, epilepsy, migraine, lumbar disc lesions, polyneuropathy, parkinsonism, brain atrophy, after craniocerebral trauma, in Kleine-Levin syndrome. The authors are studying now the course of FDP changes in the CSF in various cases in the aspect of clinical-laboratory correlations.