作为抗疟药物来源的植物：某些苦木素类化合物的体外抗疟活性
Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids.
作者信息
O'Neill M J, Bray D H, Boardman P, Phillipson J D, Warhurst D C, Peters W, Suffness M
出版信息
Antimicrob Agents Chemother. 1986 Jul;30(1):101-4. doi: 10.1128/AAC.30.1.101.
Abstract
Fourteen quassinoids, obtained from simaroubaceous plants, were tested for in vitro antimalarial activity. All of these inhibited the incorporation of [3H]hypoxanthine into Plasmodium falciparum in vitro at concentrations below 0.41 microgram ml-1. The two most potent quassinoids, bruceantin and simalikalactone D, showed 50% inhibitory concentration values of 0.0008 and 0.0009 microgram ml-1, respectively. The results are compared with the antiamoebic, antileukemic, and cytotoxic activities of these compounds reported in the literature.
摘要
从苦木科植物中提取的14种苦木素类化合物进行了体外抗疟活性测试。所有这些化合物在浓度低于0.41微克/毫升时均能抑制[3H]次黄嘌呤在恶性疟原虫中的体外掺入。两种活性最强的苦木素类化合物，鸦胆子苦素和刺桐苦内酯D，其半数抑制浓度值分别为0.0008和0.0009微克/毫升。将这些结果与文献中报道的这些化合物的抗阿米巴、抗白血病和细胞毒性活性进行了比较。
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Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica.鸦胆子素，一种从植物鸦胆子中提取的强效杀阿米巴剂。
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