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作为抗疟药物来源的植物：某些苦木素类化合物的体外抗疟活性

Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids.

作者信息

O'Neill M J, Bray D H, Boardman P, Phillipson J D, Warhurst D C, Peters W, Suffness M

出版信息

Antimicrob Agents Chemother. 1986 Jul;30(1):101-4. doi: 10.1128/AAC.30.1.101.

DOI:10.1128/AAC.30.1.101
PMID:3530122
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176444/
Abstract

Fourteen quassinoids, obtained from simaroubaceous plants, were tested for in vitro antimalarial activity. All of these inhibited the incorporation of [3H]hypoxanthine into Plasmodium falciparum in vitro at concentrations below 0.41 microgram ml-1. The two most potent quassinoids, bruceantin and simalikalactone D, showed 50% inhibitory concentration values of 0.0008 and 0.0009 microgram ml-1, respectively. The results are compared with the antiamoebic, antileukemic, and cytotoxic activities of these compounds reported in the literature.

摘要

从苦木科植物中提取的14种苦木素类化合物进行了体外抗疟活性测试。所有这些化合物在浓度低于0.41微克/毫升时均能抑制[3H]次黄嘌呤在恶性疟原虫中的体外掺入。两种活性最强的苦木素类化合物，鸦胆子苦素和刺桐苦内酯D，其半数抑制浓度值分别为0.0008和0.0009微克/毫升。将这些结果与文献中报道的这些化合物的抗阿米巴、抗白血病和细胞毒性活性进行了比较。

相似文献

1
Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids.作为抗疟药物来源的植物：某些苦木素类化合物的体外抗疟活性
Antimicrob Agents Chemother. 1986 Jul;30(1):101-4. doi: 10.1128/AAC.30.1.101.
2
Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids.采用微量稀释法评估鸦胆子果实、苦木科植物苦木茎以及多种喹啉类化合物的体外抗阿米巴活性。
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本文引用的文献

1
In vitro and in vivo assessement of the antimalarial activity of sergeolide.体外和体内评估 Sergeolide 的抗疟活性。
Planta Med. 1985 Feb;51(1):20-3. doi: 10.1055/s-2007-969382.
2
Antimalarial drug resistance: an increasing problem.抗疟药耐药性：一个日益严重的问题。
Br Med Bull. 1982 May;38(2):187-92. doi: 10.1093/oxfordjournals.bmb.a071757.
3
Antimalarial activity of quassinoids against chloroquine-resistant Plasmodium falciparum in vitro.苦木素类化合物对氯喹耐药恶性疟原虫的体外抗疟活性
Am J Trop Med Hyg. 1981 May;30(3):531-7. doi: 10.4269/ajtmh.1981.30.531.
4
Anti-inflammatory agents III: Structure-activity relationships of brusatol and related quassinoids.抗炎剂III：布鲁斯醇及相关苦木素类化合物的构效关系
J Pharm Sci. 1983 Nov;72(11):1282-4. doi: 10.1002/jps.2600721111.
5
Antimalarial activity of bruceantin in vitro.鸦胆子苦素的体外抗疟活性。
Ann Trop Med Parasitol. 1983 Aug;77(4):433-5. doi: 10.1080/00034983.1983.11811732.
6
Susceptibility of Plasmodium falciparum to five drugs: an in vitro study of isolates mainly from Thailand.恶性疟原虫对五种药物的敏感性：一项主要针对泰国分离株的体外研究
Trans R Soc Trop Med Hyg. 1983;77(2):228-31. doi: 10.1016/0035-9203(83)90080-9.
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Experimental amoebiasis and the development of anti-amoebic compounds.实验性阿米巴病与抗阿米巴化合物的研发
Parasitology. 1983 Feb;86 (Pt 1):175-91. doi: 10.1017/s0031182000057279.
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Structural requirements of quassinoids for the inhibition of cell transformation.苦木素类化合物抑制细胞转化的结构要求
Biochem Biophys Res Commun. 1980 Apr 14;93(3):675-86. doi: 10.1016/0006-291x(80)91131-6.
9
Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica.鸦胆子素，一种从植物鸦胆子中提取的强效杀阿米巴剂。
Antimicrob Agents Chemother. 1982 Aug;22(2):342-5. doi: 10.1128/AAC.22.2.342.
10
Plants as sources of antimalarial drugs. Part 1. In vitro test method for the evaluation of crude extracts from plants.植物作为抗疟药物的来源。第1部分。植物粗提物评价的体外试验方法。
Planta Med. 1985 Oct;51(5):394-8. doi: 10.1055/s-2007-969529.