鼠冠状病毒在鼠成纤维细胞与大鼠雪旺氏细胞瘤细胞之间的体细胞杂种中的复制
Replication of murine coronaviruses in somatic cell hybrids between murine fibroblasts and rat schwannoma cells.
作者信息
Flintoff W F
出版信息
Virology. 1984 Apr 30;134(2):450-9. doi: 10.1016/0042-6822(84)90312-x.
Abstract
The replication of the murine coronaviruses MHV3 and JHM has been studied in somatic cell hybrids formed between murine fibroblast L2 cells which support lytic infections with both these agents, and rat RN2 Schwannoma cells which support the replication of JHM in a temperature-sensitive, persistent manner but are restrictive to the replication of MHV3. The results described in this report indicate that the totally permissive state is dominant over the persistent or restricted state since the hybrid cells permit the replication of both these viral agents in a lytic manner.
摘要
小鼠冠状病毒MHV3和JHM在体细胞杂种中的复制情况已得到研究。这些体细胞杂种由小鼠成纤维细胞L2细胞与大鼠RN2雪旺细胞瘤细胞形成，其中L2细胞支持这两种病毒的溶细胞性感染，而RN2雪旺细胞瘤细胞以温度敏感的持续性方式支持JHM的复制，但对MHV3的复制具有限制性。本报告中描述的结果表明，完全允许状态对持续性或限制性状态占主导地位，因为杂种细胞允许这两种病毒以溶细胞方式进行复制。
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