Burny A, Bruck C, Cleuter Y, Couez D, Deschamps J, Ghysdael J, Grégoire D, Kettmann R, Mammerickx M, Marbaix G
Cancer Res. 1985 Sep;45(9 Suppl):4578s-4582s.
The bovine leukemia virus is the etiological agent of a chronic lymphatic leukemia in cows, sheep, and goats. The same virus seems to induce a kind of wasting disease in experimentally infected rabbits. Antibodies to highly purified bovine leukemia viral Mr 51,000 glycoprotein and Mr 24,000 protein cross-react with human T-lymphotropic virus III/lymphadenopathy-associated virus antigens present in cultured lymphocytes of African patients suffering from acquired immune deficiency syndrome. Bovine leukemia virus has many structural and functional characteristics in common with the human T-lymphotropic viruses. The most striking feature of these retroviruses is the existence of a long open reading frame located at the 3' side of the provirus between the right end of the 3' side of env gene and the left end of the long terminal repeat. It is believed that the long open reading frame protein product acts in trans upon a number of genes to account for the biological effects of the virus.
牛白血病病毒是牛、绵羊和山羊慢性淋巴细胞白血病的病原体。同一病毒似乎在实验感染的兔子中诱发一种消瘦病。针对高度纯化的牛白血病病毒51,000分子量糖蛋白和24,000分子量蛋白的抗体，与存在于患有获得性免疫缺陷综合征的非洲患者培养淋巴细胞中的人类嗜T淋巴细胞病毒III/淋巴结病相关病毒抗原发生交叉反应。牛白血病病毒与人类嗜T淋巴细胞病毒有许多结构和功能特征相同。这些逆转录病毒最显著的特征是在原病毒的3'侧，env基因3'侧右端与长末端重复序列左端之间存在一个长开放阅读框。据信，长开放阅读框蛋白产物以反式作用于多个基因，以解释病毒的生物学效应。
