Weissberg P L, West M J, Wilkins M R, Kricka L J
J Hypertens Suppl. 1984 Dec;2(3):S511-3.
Twenty-two young normotensive male subjects, 12 with an established family history of essential hypertension, were put on a low-followed by a high-sodium diet. Plasma from each dietary period was tested for inhibitory activity on Na-K-ATPase using three different techniques: measurement of 22Na efflux rate, measurement of 3H ouabain binding characteristics and a bioluminescent adenosine triphosphate assay. The high-sodium diet was associated with a diminished ouabain-sensitive sodium efflux rate constant in the whole group; however, no circulating inhibitor could be detected in the plasma. Those with and those without a family history of essential hypertension were indistinguishable. The results suggest that young normotensive individuals with a genetic predisposition to essential hypertension do not produce a circulating inhibitor of sodium-potassium adenosine triphosphatase (Na-K-ATPase) in response to a high-sodium challenge.
22名血压正常的年轻男性受试者，其中12人有原发性高血压家族史，他们先采用低钠饮食，然后改为高钠饮食。使用三种不同技术检测每个饮食阶段血浆对钠钾ATP酶的抑制活性：测量22Na外流率、测量3H哇巴因结合特性以及生物发光三磷酸腺苷测定。高钠饮食与全组哇巴因敏感性钠外流速率常数降低有关；然而，血浆中未检测到循环抑制剂。有和没有原发性高血压家族史的人没有区别。结果表明，对原发性高血压有遗传易感性的年轻血压正常个体在高钠刺激下不会产生钠钾三磷酸腺苷酶（Na-K-ATPase）的循环抑制剂。
