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用放射性标记的人单克隆抗体对恶性胶质瘤进行定位

Localisation of malignant glioma by a radiolabelled human monoclonal antibody.

作者信息

Phillips J, Alderson T, Sikora K, Watson J

机构信息

Department of Neurosurgery, St. Laurence's Hospital, Dublin.

出版信息

J Neurol Neurosurg Psychiatry. 1983 May;46(5):388-92. doi: 10.1136/jnnp.46.5.388.

DOI:10.1136/jnnp.46.5.388
PMID:6101173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1027384/
Abstract

Human monoclonal antibodies were produced by fusing intratumoral lymphocytes from patients with malignant gliomas with a human myeloma line. One antibody was selected for further study after screening for binding activity to glioma cell lines. The patient from whom it was derived developed recurrent glioma. 1 mg of antibody was purified, radiolabelled with 131I, and administered intravenously. The distribution of antibody was determined in the blood, CSF and tumour cyst fluid and compared with that of a control human monoclonal immunoglobulin. Antibody localisation in the tumour was observed and confirmed by external scintiscanning.

摘要

通过将恶性胶质瘤患者的瘤内淋巴细胞与一种人骨髓瘤细胞系融合来制备人单克隆抗体。在筛选出与胶质瘤细胞系的结合活性后，选择了一种抗体进行进一步研究。产生该抗体的患者发生了复发性胶质瘤。纯化1毫克抗体，用131I进行放射性标记，然后静脉注射。测定抗体在血液、脑脊液和肿瘤囊液中的分布，并与对照人单克隆免疫球蛋白的分布进行比较。通过外部闪烁扫描观察并确认抗体在肿瘤中的定位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bac/1027384/5aefbb94cbd0/jnnpsyc00133-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bac/1027384/abe29c7357d2/jnnpsyc00133-0017-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bac/1027384/85bb7cfc4b0c/jnnpsyc00133-0017-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bac/1027384/03dccc14331b/jnnpsyc00133-0017-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bac/1027384/5aefbb94cbd0/jnnpsyc00133-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bac/1027384/abe29c7357d2/jnnpsyc00133-0017-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bac/1027384/85bb7cfc4b0c/jnnpsyc00133-0017-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bac/1027384/03dccc14331b/jnnpsyc00133-0017-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bac/1027384/5aefbb94cbd0/jnnpsyc00133-0019-a.jpg

相似文献

1
Localisation of malignant glioma by a radiolabelled human monoclonal antibody.用放射性标记的人单克隆抗体对恶性胶质瘤进行定位
J Neurol Neurosurg Psychiatry. 1983 May;46(5):388-92. doi: 10.1136/jnnp.46.5.388.
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Radioimmunodetection of gliomas by administration of radiolabelled monoclonal antibodies. Experimental data.通过给予放射性标记单克隆抗体对胶质瘤进行放射免疫检测。实验数据。
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引用本文的文献

1
Intralesional administration of I-131 labelled monoclonal antibodies in the treatment of malignant gliomas.
Acta Neurochir (Wien). 1995;135(3-4):159-62. doi: 10.1007/BF02187762.
2
Localization of experimental glioma grafts by means of iodinated monoclonal antibodies and radionuclide imaging.通过碘化单克隆抗体和放射性核素成像对实验性胶质瘤移植物进行定位。
Acta Neuropathol. 1985;66(4):340-2. doi: 10.1007/BF00690968.
3
Radioimmunolocalization of human brain tumours: biodistribution of radiolabelled monoclonal antibody UJ13A.
Eur J Nucl Med. 1986;12(7):313-20. doi: 10.1007/BF00263810.
4

本文引用的文献

1
Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody.用单克隆抗独特型抗体治疗B细胞淋巴瘤。
N Engl J Med. 1982 Mar 4;306(9):517-22. doi: 10.1056/NEJM198203043060906.
2
Phase-I clinical trial of monoclonal antibody in treatment of gastrointestinal tumours.单克隆抗体治疗胃肠道肿瘤的I期临床试验。
Lancet. 1982 Apr 3;1(8275):762-5. doi: 10.1016/s0140-6736(82)91811-6.
3
Human hybridomas from malignant gliomas.源自恶性胶质瘤的人杂交瘤。
Neuro-oncology index and review (adult primary brain tumors). Radiotherapy, chemotherapy, immunotherapy, photodynamic therapy.神经肿瘤学索引与综述（成人原发性脑肿瘤）。放射治疗、化学疗法、免疫疗法、光动力疗法。
J Neurooncol. 1991 Oct;11(2):85-147. doi: 10.1007/BF02390173.
Lancet. 1982 Jan 2;1(8262):11-4. doi: 10.1016/s0140-6736(82)92556-9.
4
A procedure for the fusion of cells in suspension by means of polyethylene glycol.一种通过聚乙二醇使悬浮细胞融合的方法。
Somatic Cell Genet. 1977 Mar;3(2):227-30. doi: 10.1007/BF01551817.