• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大鼠肝脏中致癌物诱导的酶改变岛状区域内谷胱甘肽含量增加的组织化学证明。

Histochemical demonstration of enhanced glutathione content in enzyme-altered islands induced by carcinogens in rat liver.

作者信息

Deml E, Oesterle D

出版信息

Cancer Res. 1980 Feb;40(2):490-1.

PMID:6101309
Abstract

The presence of glutathione was demonstrated histochemically in livers of rats treated with diethylnitrosamine or N-nitrosomorpholine. Glutathione content was markedly elevated in adenosine triphosphatase-deficient, gamma-glutamyltranspeptidase-positive hyperplastic cell islands. This finding may partly explain the increased resistance of hyperplastic cells to cytotoxic actions of hepatocarcinogens.

摘要

用二乙基亚硝胺或N-亚硝基吗啉处理的大鼠肝脏中，通过组织化学方法证实了谷胱甘肽的存在。在缺乏三磷酸腺苷酶、γ-谷氨酰转肽酶阳性的增生性细胞岛中，谷胱甘肽含量显著升高。这一发现可能部分解释了增生性细胞对肝癌致癌物细胞毒性作用的抵抗力增加的原因。

相似文献

1
Histochemical demonstration of enhanced glutathione content in enzyme-altered islands induced by carcinogens in rat liver.大鼠肝脏中致癌物诱导的酶改变岛状区域内谷胱甘肽含量增加的组织化学证明。
Cancer Res. 1980 Feb;40(2):490-1.
2
Sex-dependent promoting effect of polychlorinated biphenyls on enzyme-altered islands induced by diethylnitrosamine in rat liver.多氯联苯对大鼠肝脏中由二乙基亚硝胺诱导的酶改变岛的性别依赖性促进作用。
Carcinogenesis. 1982;3(12):1449-52. doi: 10.1093/carcin/3.12.1449.
3
Dose-dependent promoting effect of polychlorinated biphenyls on enzyme-altered islands in livers of adult and weanling rats.多氯联苯对成年和断奶大鼠肝脏中酶改变岛的剂量依赖性促进作用。
Carcinogenesis. 1984 Mar;5(3):351-5. doi: 10.1093/carcin/5.3.351.
4
Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver.维生素E预处理对N-亚硝基二乙胺诱导的大鼠肝脏氧化应激的保护作用。
Chem Biol Interact. 2005 Oct 20;156(2-3):101-11. doi: 10.1016/j.cbi.2005.08.001.
5
[Histochemical appearance of gamma-glutamyltranspeptidase in the rat liver after transplacental exposure to diethylnitrosamine and postnatal administration of phenobarbital].
Eksp Onkol. 1984;6(5):30-3.
6
Inhibition of cell proliferation by ciprofibrate in glutathione S-transferase P1-1-positive rat hepatic hyperplastic nodules.环丙贝特对谷胱甘肽S-转移酶P1-1阳性大鼠肝脏增生性结节细胞增殖的抑制作用
Cancer Res. 1994 May 15;54(10):2622-9.
7
Rapid production of hyperplastic liver nodules in rats treated with carcinogenic chemicals: a new approach for an in vivo short-term screening test for hepatocarcinogens.用致癌化学物质处理的大鼠中增生性肝结节的快速产生：一种用于肝癌致癌物体内短期筛选试验的新方法。
Gan. 1977 Aug;68(4):499-507.
8
Enhancing effect of co-administration of polychlorinated biphenyls and diethylnitrosamine on enzyme-altered islands induced by diethylnitrosamine in rat liver.多氯联苯与二乙基亚硝胺联合给药对二乙基亚硝胺诱导的大鼠肝酶变灶的增强作用。
Carcinogenesis. 1986 Oct;7(10):1697-700. doi: 10.1093/carcin/7.10.1697.
9
Scanning electron microscopy of rat liver hyperplastic nodules induced by diethylnitrosamine.
Scan Electron Microsc. 1982(Pt 4):1793-8.
10
Characterization of histochemically detectable altered hepatocyte foci and their relationship to hepatic tumorigenesis in rats treated once with diethylnitrosamine or benzo(a)pyrene within one day after birth.出生后一天内单次给予二乙基亚硝胺或苯并(a)芘处理的大鼠中，组织化学可检测到的肝细胞灶改变的特征及其与肝肿瘤发生的关系。
Cancer Res. 1984 Aug;44(8):3340-7.

引用本文的文献

1
New Insights into the Role of Glutathione in the Mechanism of Fever.谷胱甘肽在发热机制中的作用的新见解。
Int J Mol Sci. 2020 Feb 19;21(4):1393. doi: 10.3390/ijms21041393.
2
Nonclonal growth of preneoplastic cells positive for glutathione S-transferase P-form in the rat liver.大鼠肝内谷胱甘肽 S-转移酶 P 型阳性的癌前期细胞的非克隆性生长。
Cancer Sci. 2012 Aug;103(8):1445-50. doi: 10.1111/j.1349-7006.2012.02325.x. Epub 2012 Jun 14.
3
Distinctive biochemical pattern associated with resistance of hepatocytes in hepatocyte nodules during liver carcinogenesis.
肝癌发生过程中与肝细胞结节中肝细胞抗性相关的独特生化模式。
Environ Health Perspect. 1983 Mar;49:171-4. doi: 10.1289/ehp.8349171.
4
gamma-Glutamyltranspeptidase: a tumour cell marker with a pharmacological function.γ-谷氨酰转肽酶：一种具有药理功能的肿瘤细胞标志物。
Histochem J. 1981 Sep;13(5):865-77. doi: 10.1007/BF01003295.
5
Tumor promotion in the liver.肝脏中的肿瘤促进作用。
Arch Toxicol. 1985 Aug;57(3):147-58. doi: 10.1007/BF00290879.
6
Glutathione localisation in benign and malignant human breast lesions.谷胱甘肽在人类乳腺良恶性病变中的定位
Br J Cancer. 1987 Jun;55(6):605-9. doi: 10.1038/bjc.1987.123.
7
Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards.与对氮芥耐药相关的α类谷胱甘肽S-转移酶编码基因的扩增及表达增加。
Proc Natl Acad Sci U S A. 1988 Nov;85(22):8511-5. doi: 10.1073/pnas.85.22.8511.
8
Glutathione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes.谷胱甘肽补充能力在分离的肝静脉周围肝细胞中比在肝门周围肝细胞中更低。
Biochem J. 1988 Sep 1;254(2):411-7. doi: 10.1042/bj2540411.
9
Enzymes of glutathione metabolism as biochemical markers during hepatocarcinogenesis.谷胱甘肽代谢酶作为肝癌发生过程中的生化标志物。
Cancer Metastasis Rev. 1987;6(2):155-78. doi: 10.1007/BF00052847.
10
Comparison of killing of gram-negative and gram-positive bacteria by pure singlet oxygen.纯单线态氧对革兰氏阴性菌和革兰氏阳性菌杀灭作用的比较。
J Bacteriol. 1989 Apr;171(4):2188-94. doi: 10.1128/jb.171.4.2188-2194.1989.