大鼠肝脏中致癌物诱导的酶改变岛状区域内谷胱甘肽含量增加的组织化学证明。
Histochemical demonstration of enhanced glutathione content in enzyme-altered islands induced by carcinogens in rat liver.
作者信息
Deml E, Oesterle D
出版信息
Cancer Res. 1980 Feb;40(2):490-1.
PMID:6101309
Abstract
The presence of glutathione was demonstrated histochemically in livers of rats treated with diethylnitrosamine or N-nitrosomorpholine. Glutathione content was markedly elevated in adenosine triphosphatase-deficient, gamma-glutamyltranspeptidase-positive hyperplastic cell islands. This finding may partly explain the increased resistance of hyperplastic cells to cytotoxic actions of hepatocarcinogens.
摘要
用二乙基亚硝胺或N-亚硝基吗啉处理的大鼠肝脏中，通过组织化学方法证实了谷胱甘肽的存在。在缺乏三磷酸腺苷酶、γ-谷氨酰转肽酶阳性的增生性细胞岛中，谷胱甘肽含量显著升高。这一发现可能部分解释了增生性细胞对肝癌致癌物细胞毒性作用的抵抗力增加的原因。
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