Qureshi A A, Burger W C, Prentice N, Bird H R, Sunde M L
J Nutr. 1980 Mar;110(3):388-93. doi: 10.1093/jn/110.3.388.
The activities of acetyl-CoA carboxylase (EC 6.4.1.2), fatty acid synthetase (FAS) and beta-hydroxy-beta-methylglutaryl-CoA (HMG-CoA) reductase (EC 1.1.1.88) were determined in subcellular fractions of livers from chicks fed different cereal-based diets. With a barley-based diet as compared to corn, the following was observed: body and liver weights decreased 31%; HMG-CoA reductase activity of liver decreased 79%; acetyl-CoA carboxylase activity increased 3-fold; fatty acid synthesis increased 5-fold, and plasma and liver cholesterol decreased 45% and 35%, respectively. The suppression and induction of activities of the two divergent pathways (cholesterol and fatty acid biosynthesis) persisted for at least 21 days. Wheat, oats and rye showed a similar but less pronounced effect. The pronounced decrease in plasma cholesterol level and HMG-CoA reductase activity have implications for human nutrition and possible control of the cardiovascular diseases in which cholesterol plays a key role.
测定了喂食不同谷物类日粮的雏鸡肝脏亚细胞组分中乙酰辅酶A羧化酶（EC 6.4.1.2）、脂肪酸合成酶（FAS）和β-羟基-β-甲基戊二酰辅酶A（HMG-CoA）还原酶（EC 1.1.1.88）的活性。与以玉米为基础的日粮相比，以大麦为基础的日粮出现了以下情况：体重和肝脏重量下降了31%；肝脏中HMG-CoA还原酶活性下降了79%；乙酰辅酶A羧化酶活性增加了3倍；脂肪酸合成增加了5倍，血浆和肝脏中的胆固醇分别下降了45%和35%。这两条不同途径（胆固醇和脂肪酸生物合成）的活性抑制和诱导持续了至少21天。小麦、燕麦和黑麦表现出类似但不太明显的效果。血浆胆固醇水平和HMG-CoA还原酶活性的显著降低对人类营养以及可能控制胆固醇起关键作用的心血管疾病具有重要意义。
