成人哮喘中的酮替芬
Ketotifen in adult asthma.
作者信息
Dyson A J, Mackay A D
出版信息
Br Med J. 1980 Feb 9;280(6211):360-1. doi: 10.1136/bmj.280.6211.360.
Abstract
The efficacy and adverse effects of ketotifen 1 mg twice daily and 2 mg twice daily were compared with placebo in 50 patients with atopic asthma in a multicentre, double-blind study. Ketotifen in the higher dosage caused a slight reduction in salbutamol usage and a modest improvement in breathing in patients not already receiving inhaled corticosteroids. The drug was ineffective in patients receiving inhaled corticosteroids. Drowsiness was a troublesome effect causing withdrawal from treatment or reduction of dosage in seven patients while receiving ketotifen compared with only three while receiving placebo.
摘要
在一项多中心、双盲研究中，对50例特应性哮喘患者比较了每日两次服用1毫克和每日两次服用2毫克酮替芬与安慰剂的疗效及不良反应。较高剂量的酮替芬使未接受吸入性糖皮质激素治疗的患者沙丁胺醇用量略有减少，呼吸功能有一定改善。该药物对接受吸入性糖皮质激素治疗的患者无效。嗜睡是一个麻烦的副作用，服用酮替芬时有7例患者因嗜睡而停药或减量，而服用安慰剂时只有3例。
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本文引用的文献
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A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma.色甘酸钠治疗过敏性支气管哮喘的双盲试验。
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A placebo-controlled trial of ketotifen (HC 20-511, Sandoz) in allergen induced asthma and comparison with disodium cromoglycate.酮替芬（HC 20 - 511，山德士公司）治疗变应原诱发哮喘的安慰剂对照试验及与色甘酸二钠的比较
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Comparison between ketotifen and DSCG in bronchial challenge.酮替芬与色甘酸二钠在支气管激发试验中的比较。
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Arzneimittelforschung. 1978;28(5):770-82.
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