酮替芬（HC 20 - 511）与色甘酸钠（SCG）对皮肤试验阳性哮喘疗效的比较
A comparison of the efficacy of ketotifen (HC 20-511) with sodium cromoglycate (SCG) in skin test positive asthma.
作者信息
Clarke C W, May C S
出版信息
Br J Clin Pharmacol. 1980 Nov;10(5):473-6. doi: 10.1111/j.1365-2125.1980.tb01791.x.
Abstract
1 Ketotifen (HC 20-511 Sandoz) 1 mg twice daily for 12 weeks was found to be equivalent to sodium cromoglycate (SCG) 20 mg four times daily for 12 weeks in 35 skin test positive asthmatic patients in a randomised double-blind cross-over study. 2 No statistically significant difference between the two drugs in mean values for daily peak flow rates, diary card scores and spirometry at monthly visits was demonstrated. 3 Treatment failures as judged by severe asthma requiring withdrawal from the trial or addition of short courses of prednisone occurred in three patients on each drug. 4 Sedation was noted by 10 patients onHC 20-511 and 5 on SCG. 5 Weight loss was noted in those patients on SCG, but not those on HC 20-511.
摘要
- 在一项随机双盲交叉研究中，发现35名皮肤试验呈阳性的哮喘患者服用酮替芬（HC 20 - 511，山德士公司生产）1毫克，每日两次，共12周，与服用色甘酸钠（SCG）20毫克，每日四次，共12周效果相当。2. 每月随访时，两种药物在每日最高呼气流量均值、日记卡评分和肺活量测定方面，未显示出统计学上的显著差异。3. 每种药物各有3名患者因严重哮喘需要退出试验或加用短期泼尼松治疗而判定为治疗失败。4. 10名服用HC 20 - 511的患者和5名服用SCG的患者出现了镇静作用。5. 服用SCG的患者出现了体重减轻，但服用HC 20 - 511的患者未出现。
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本文引用的文献
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Clin Allergy. 1979 May;9(3):237-40. doi: 10.1111/j.1365-2222.1979.tb01548.x.
2
Clinical investigation of agents with prophylactic anti-allergic effects in bronchial asthma.支气管哮喘预防性抗过敏药物的临床研究
Clin Allergy. 1978 Jul;8(4):373-82. doi: 10.1111/j.1365-2222.1978.tb00472.x.
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