Khogali M, Weiner J S
Lancet. 1980 Aug 9;2(8189):276-8. doi: 10.1016/s0140-6736(80)90232-9.
Eighteen hyperpyrexial patients with a mean rectal temperature of 42.3 degrees (range 41.2-43.1 degrees C) were rapidly cooled in a unit producing evaporative cooling from a warm skin. Sixteen patients recovered, and two, who were diabetic, died. The time taken for the core temperature to drop to 38 degrees C varied from 26 min to 5 h. The success of a treatment which maintained vasodilatation by warming the skin accords with the hypothesis that peripheral vasoconstriction combined with a high metabolic heat output is a major factor in the pathogenesis of heat stroke.
18名高热患者，平均直肠温度为42.3摄氏度（范围41.2 - 43.1摄氏度），在一个通过温暖皮肤产生蒸发冷却的装置中迅速降温。16名患者康复，2名糖尿病患者死亡。核心温度降至38摄氏度所需时间从26分钟到5小时不等。通过温暖皮肤维持血管扩张的治疗方法取得成功，这与以下假设相符：外周血管收缩与高代谢产热相结合是中暑发病机制的一个主要因素。
