Dickinson R J, Dixon M F, Axon A T
Lancet. 1980 Sep 20;2(8195 pt 1):620-2. doi: 10.1016/s0140-6736(80)90286-x.
The role of colonoscopy in the surveillance of patients with ulcerative colitis for dysplasia was investigated in 43 patients with longstanding disease extending proximally beyond the splenic flexure. The examination was well tolerated and no complications were recorded. Dysplasia was found in 9 patients in one or more biopsies and was severe in 2, moderate in 1, and mild in 6. Both the patients with severe dysplasia had a carcinoma at subsequent operation. Colonoscopy may allow complete examination of the colon and biopsy of suspicious lesions and, since dysplasia may spare the rectum, colonoscopy with biopsy is a desirable component of any surveillance programme of the at-risk colitic.
对43例病变长期累及脾曲近端的溃疡性结肠炎患者进行结肠镜检查，以评估其在发育异常监测中的作用。检查耐受性良好，未记录到并发症。在9例患者的一处或多处活检中发现发育异常，其中重度2例，中度1例，轻度6例。2例重度发育异常患者在后续手术中发现癌变。结肠镜检查可对结肠进行全面检查并对可疑病变进行活检，而且由于发育异常可能不累及直肠，因此结肠镜检查及活检是任何高危结肠炎监测方案中理想的组成部分。
