Rylance H J, Chalmers T M, Elton R A
Lancet. 1980 Nov 22;2(8204):1099-102. doi: 10.1016/s0140-6736(80)92539-8.
The effect of the intra-articular injection of acetylsalicylic acid in patients with rheumatoid arthritis was compared with that of hydrocortisone acetate and with that of saline in blind, controlled, clinical trials. All three preparations were effective in relieving pain and improving the range of motion, and no significant differences were demonstrated. The results suggest a need for the re-appraisal of the value of intra-articular administration of synthetic corticosteroids.
在盲法对照临床试验中，对类风湿性关节炎患者关节腔内注射乙酰水杨酸的效果与注射醋酸氢化可的松以及注射生理盐水的效果进行了比较。所有这三种制剂在缓解疼痛和改善活动范围方面均有效，且未显示出显著差异。结果表明有必要重新评估关节腔内注射合成皮质类固醇的价值。
