Christophidis N, Huskisson E C
Rheumatol Int. 1982;2(3):129-32. doi: 10.1007/BF00541165.
Six patients (4 men, 2 women) with moderate/large knee effusions due to rheumatoid arthritis (RA) were studied after receiving indoprofen, 25 mg intra-articularly and then 200 mg orally 1 week later. There was significant improvement in pain (t = 3.74, P less than 0.05), morning stiffness (t = 2.91, P less than 0.05) and range of movement (t = 2.52, P less than 0.05) for at least 1 week following the intra-articular injection. The terminal phase plasma half-life after the 200 mg oral dose was 6.4 +/- 0.7 h (mean +/- SEM) and was significantly longer than the often quoted plasma half-life of 2-3 h from previous studies, but much less than the pharmacodynamic half-life. Synovial fluid concentration were not significantly different from those in plasma in the post-distribution phase. Intra-articular indoprofen may be a useful addition to the treatment of RA.
对6例因类风湿性关节炎（RA）导致膝关节中/大量积液的患者（4例男性，2例女性）进行了研究，患者先接受关节腔内注射25mg吲哚美辛，1周后口服200mg。关节腔内注射后至少1周，疼痛（t = 3.74，P < 0.05）、晨僵（t = 2.91，P < 0.05）和活动范围（t = 2.52，P < 0.05）均有显著改善。口服200mg剂量后的终末相血浆半衰期为6.4±0.7小时（均值±标准误），显著长于以往研究中常引用的2 - 3小时的血浆半衰期，但远短于药效学半衰期。分布后相中，滑液浓度与血浆浓度无显著差异。关节腔内注射吲哚美辛可能是类风湿性关节炎治疗中的一种有用补充。
