Jones R J, Roe E A, Gupta J L
Lancet. 1980 Dec 13;2(8207):1263-5. doi: 10.1016/s0140-6736(80)92334-x.
In a controlled trial burn patients at risk of Pseudomonas aeruginosa septicaemia were passively immunised with an immunoglobulin prepared from plasma from healthy human volunteers vaccinated with a polyvalent pseudomonas vaccine; passively immunised and vaccinated; or only vaccinated. In children the mortality was lowest in those passively immunised (0%, 0/18); it was 21% (9/42) in controls. In adults the mortality rate of those receiving immunoglobulin or vaccine was 10% (3/30) or 8.3% (5/60), respectively, compared with 36% (22/61) in controls. Combined vaccine and immunoglobulin treatment gave rather less protection (mortality 13.6%, 3/22) than vaccine alone. Pseudomonas infection of burns was less common in patients who received immunoglobulin than in vaccinated or control patients.
在一项对照试验中，对有患铜绿假单胞菌败血症风险的烧伤患者进行了如下处理：用从接种多价铜绿假单胞菌疫苗的健康人类志愿者血浆中制备的免疫球蛋白进行被动免疫；进行被动免疫并接种疫苗；或仅接种疫苗。在儿童中，被动免疫组的死亡率最低（0%，0/18）；对照组的死亡率为21%（9/42）。在成人中，接受免疫球蛋白或疫苗者的死亡率分别为10%（3/30）或8.3%（5/60），而对照组为36%（22/61）。联合使用疫苗和免疫球蛋白治疗提供的保护作用比单独使用疫苗略少（死亡率13.6%，3/22）。接受免疫球蛋白的患者烧伤部位的铜绿假单胞菌感染比接种疫苗或对照组患者少见。
