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J Clin Invest. 1982 Feb;69(2):303-8. doi: 10.1172/jci110453.
2
Structural analysis and immunogenicity of Pseudomonas aeruginosa immunotype 2 high molecular weight polysaccharide.铜绿假单胞菌免疫型2高分子量多糖的结构分析与免疫原性
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3
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4
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Characterization of the human immune response to a polysaccharide vaccine from Pseudomonas aeruginosa.人对铜绿假单胞菌多糖疫苗免疫反应的特征分析
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Immunologic basis for mouse protection provided by high-molecular-weight polysaccharide from immunotype 1 Pseudomonas aeruginosa.1型铜绿假单胞菌高分子量多糖对小鼠的保护作用的免疫学基础。
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Antibiot Chemother (1971). 1989;42:177-83. doi: 10.1159/000417618.
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8
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本文引用的文献

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Agar-Gel Precipitating Antibody in Pseudomonas aeruginosa Infections.绿脓假单胞菌感染中的琼脂凝胶沉淀抗体。
Infect Immun. 1970 Oct;2(4):495-503. doi: 10.1128/iai.2.4.495-503.1970.
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Correlation of the biologic responses of C3H/HEJ mice to endotoxin with the chemical and structural properties of the lipopolysaccharides from Pseudomonas aeruginosa and Escherichia coli.C3H/HEJ小鼠对内毒素的生物学反应与铜绿假单胞菌和大肠杆菌脂多糖的化学及结构特性的相关性。
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High-molecular-weight polysaccharide antigen from Pseudomonas aeruginosa immunotype 2.来自铜绿假单胞菌免疫型2的高分子量多糖抗原。
Infect Immun. 1981 Nov;34(2):461-8. doi: 10.1128/iai.34.2.461-468.1981.
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Controlled trial of Pseudomonas immunoglobulin and vaccine in burn patients.烧伤患者使用假单胞菌免疫球蛋白和疫苗的对照试验。
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Human immunity to Pseudomonas aeruginosa. II. Relationship between heat-stable opsonins and type-specific lipopolysaccharides.人类对铜绿假单胞菌的免疫力。II. 热稳定调理素与型特异性脂多糖之间的关系。
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Human immunity to Pseudomonas aeruginosa. I. In-vitro interaction of bacteria, polymorphonuclear leukocytes, and serum factors.人类对铜绿假单胞菌的免疫力。I. 细菌、多形核白细胞和血清因子的体外相互作用。
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Pseudomonas aeruginosa vaccine in cancer patients.癌症患者中的铜绿假单胞菌疫苗。
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Immunization against Pseudomonas in infection after thermal injury.烧伤后感染中针对铜绿假单胞菌的免疫接种。
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1型铜绿假单胞菌高分子量多糖疫苗的安全性和免疫原性。

Safety and immunogenicity of high molecular weight polysaccharide vaccine from immunotype 1 Pseudomonas aeruginosa.

作者信息

Pier G B

出版信息

J Clin Invest. 1982 Feb;69(2):303-8. doi: 10.1172/jci110453.

DOI:10.1172/jci110453
PMID:6799548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC370979/
Abstract

The safety and immunogenicity of a high molecular weight polysaccharide from immunotype 1 Pseudomonas aeruginosa were tested in a dose response fashion in adult volunteers. The vaccine lacked toxicity and pyrogenicity for experimental animals. Doses of 50, 75, 150, or 250 microgram were given to groups of individuals as a single dose subcutaneous injection. Doses of 150 and 250 microgram were associated with a significant rise in binding and opsonic antibody at 2 wk postimmunization. Titers remained unchanged for up to 6 mo. The vaccine was almost devoid of toxicity, eliciting no more than a slightly sore and tender arm at the site of injection. High molecular weight polysaccharide antigen appears to induce a good immune response following vaccination that is effective in mediating opsonophagocytic killing of live P. aeruginosa organisms.

摘要

在成年志愿者中以剂量反应方式测试了1型铜绿假单胞菌高分子量多糖的安全性和免疫原性。该疫苗对实验动物无毒性和致热原性。将50、75、150或250微克剂量作为单剂量皮下注射给予不同组的个体。150和250微克剂量在免疫后2周时与结合抗体和调理素抗体的显著升高相关。滴度在长达6个月内保持不变。该疫苗几乎没有毒性，仅在注射部位引起手臂轻微疼痛和压痛。高分子量多糖抗原在接种疫苗后似乎能诱导良好的免疫反应，有效地介导对活铜绿假单胞菌的调理吞噬杀伤作用。