Pounder R E
Lancet. 1981 Jan 3;1(8210):29-30. doi: 10.1016/s0140-6736(81)90128-8.
The duodenal ulcer healing and relapse rates reported in studies of short-term and long-term treatment with cimetidine or placebo have been used to predict the results of three treatment strategies. By far the greatest benefit of cimetidine is obtained when the drug is given as continuous low-dose maintenance therapy, with a full-dose at times of relapse.
在使用西咪替丁或安慰剂进行短期和长期治疗的研究中所报告的十二指肠溃疡愈合率和复发率,已被用于预测三种治疗策略的结果。到目前为止,当将西咪替丁作为持续低剂量维持疗法给药,并在复发时给予全剂量时,可获得最大益处。