Black R E, Merson M H, Huq I, Alim A R, Yunus M
Lancet. 1981 Jan 17;1(8212):141-3. doi: 10.1016/s0140-6736(81)90719-4.
In a 1 year study of diarrhoea in a village in rural Bangladesh, enterotoxigenic Escherichia coli (ETEC) were the most frequently detected enteropathogens; shigellae were the second most commonly detected enteropathogens and rotaviruses the third. ETEC and rotavirus were found in 31% of diarrhoea episodes experienced by children aged less than 2 years and in 70% of episodes associated with dehydration. Furthermore these two pathogens were identified in the stools of 77% of young children with life-threatening dehydration seen at a diarrhoea treatment centre. The association of ETEC and rotavirus with such a substantial proportion of cases of dehydrating diarrhoea suggests that immunoprophylaxis to reduce the high incidence of deaths from diarrhoea in developing countries may be feasible and that vaccine development should concentrate on these two enteropathogens.
在对孟加拉国农村一个村庄进行的为期1年的腹泻研究中，产肠毒素大肠杆菌（ETEC）是最常检测到的肠道病原体；志贺氏菌是第二常见的肠道病原体，轮状病毒排第三。在2岁以下儿童经历的腹泻发作中，31%检测出ETEC和轮状病毒，在与脱水相关的发作中，这一比例为70%。此外，在腹泻治疗中心出现危及生命脱水情况的幼儿粪便中，77%检测出这两种病原体。ETEC和轮状病毒与如此大比例的脱水腹泻病例相关，这表明在发展中国家，通过免疫预防来降低腹泻导致的高死亡率可能是可行的，并且疫苗研发应集中在这两种肠道病原体上。
