肾上腺素诱导性高血压中的血脑屏障。昼夜节律变化及β-肾上腺素能受体拮抗剂的影响

The blood-brain barrier in adrenaline-induced hypertension. Circadian variations and modification by beta-adrenoreceptor antagonists.

作者信息

Johansson B B, Martinsson L

出版信息

Acta Neurol Scand. 1980 Aug;62(2):96-102. doi: 10.1111/j.1600-0404.1980.tb03009.x.

DOI:10.1111/j.1600-0404.1980.tb03009.x

Abstract

Rats were subjected to adrenaline-induced acute hypertension during either the day or night. Albumin leakage into the brain was studied with Evans blue and 125I labeled serum albumin. The leakage was significantly lower during the night than during the day (P less than 0.001). d,1-propranolol had a protective effect (P less than 0.001) during the day and a slight reduction of the radioactivity (P less than 0.05 in some parts of the brain) was obtained by metoprolol (10 mg/kg) but not by butoxamine (10 mg/kg). None of the drugs reduced the tracer leakage during the night. The results suggest that the degree of alertness is of importance for the function of the blood-brain barrier in acute hypertension. However, the present experimental situation does not allow a separation of the effect of alertness per se and dark/light cycles. The changed vulnerability during the night could be related to enhanced neuronal activity, altered beta-adrenoreceptor sensitivity or to hormonal factors.

摘要

大鼠在白天或夜晚接受肾上腺素诱导的急性高血压。用伊文思蓝和125I标记的血清白蛋白研究白蛋白向脑内的渗漏情况。夜间的渗漏明显低于白天（P<0.001）。白天，d,1-普萘洛尔具有保护作用（P<0.001），美托洛尔（10mg/kg）可使放射性稍有降低（在脑的某些部位P<0.05），但布托沙明（10mg/kg）则无此作用。夜间，这些药物均未降低示踪剂的渗漏。结果提示，在急性高血压时，警觉程度对血脑屏障功能很重要。然而，目前的实验情况不允许区分警觉本身的作用和明暗周期的影响。夜间易损性的改变可能与神经元活动增强、β-肾上腺素能受体敏感性改变或激素因素有关。