生长抑素对豚鼠胃黏膜分散细胞的直接作用。
Direct action of somatostatin on dispersed mucosal cells from guinea-pig stomach.
作者信息
Batzri S
出版信息
Biochim Biophys Acta. 1981 Nov 5;677(3-4):521-4. doi: 10.1016/0304-4165(81)90268-3.
PMID:6117331
Abstract
In dispersed mucosal cells from guinea-pig stomach, somatostatin inhibited in a noncompetitive fashion (Ki, 2 x 10(-8) M) the increase in cellular cyclic AMP caused by histamine but not by prostaglandin E1 or phosphodiesterase inhibitors. Somatostatin also inhibited the increase in [14C]aminopyrine uptake caused by low concentrations of histamine probably by interfering with the synthesis of cellular cyclic AMP.
摘要
在豚鼠胃的分散黏膜细胞中，生长抑素以非竞争性方式（Ki为2×10⁻⁸M）抑制组胺引起的细胞内环磷酸腺苷（cAMP）增加，但不抑制前列腺素E1或磷酸二酯酶抑制剂引起的cAMP增加。生长抑素还可能通过干扰细胞cAMP的合成，抑制低浓度组胺引起的[¹⁴C]氨基比林摄取增加。
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