Dammann H G, Müller P, Kather H, Simon B
Res Exp Med (Berl). 1981;178(2):151-4. doi: 10.1007/BF01851489.
The antisecretory effects of a new histamine H2-receptor antagonist, ranitidine hydrochloride, have been investigated on basal and pentagastrin-stimulated acid secretion in healthy volunteers 5 and 10 h after oral administration of 150 mg. In addition, the 24-h intragastric pH-profiles have been measured in patients undergoing parenteral nutrition after three doses of 150 mg ranitidine per day. A 40% inhibition of basal acid output has been noted even 10 h after drug intake. The intragastric pH-values were raised above 5 for at least 24 h. The new H2-antagonist ranitidine has been proven to be a potent and long-acting antisecretory compound.
一种新型组胺H2受体拮抗剂盐酸雷尼替丁对健康志愿者口服150毫克后5小时和10小时基础胃酸分泌及五肽胃泌素刺激胃酸分泌的抗分泌作用进行了研究。此外，对接受肠外营养的患者每天服用三剂150毫克雷尼替丁后的24小时胃内pH值变化情况进行了测量。即使在服药10小时后，基础胃酸分泌也受到了40%的抑制。胃内pH值至少在24小时内升高至5以上。新型H2拮抗剂雷尼替丁已被证明是一种强效且长效的抗分泌化合物。
