枯草芽孢杆菌中嘧啶生物合成酶的协同合成
Coordinate synthesis of the enzymes of pyrimidine biosynthesis in Bacillus subtilis.
作者信息
Paulus T J, McGarry T J, Shekelle P G, Rosenzweig S, Switzer R L
出版信息
J Bacteriol. 1982 Feb;149(2):775-8. doi: 10.1128/jb.149.2.775-778.1982.
Abstract
Strains of Bacillus subtilis that were resistant to repression of pyrimidine nucleotide biosynthetic enzymes were selected by isolating spontaneous uracil-tolerant derivatives of a uracil-sensitive strain, which lacks arginine-repressible carbamyl phosphate synthetase. The relative content of all six enzymes of uridylic acid biosynthesis de novo in these strains was in a constant ratio over a 10-fold range of derepression, which indicates that synthesis of these enzymes is coordinately regulated.
摘要
通过分离一株尿嘧啶敏感型菌株（该菌株缺乏精氨酸可阻遏的氨甲酰磷酸合成酶）的自发耐尿嘧啶衍生物，筛选出对嘧啶核苷酸生物合成酶阻遏具有抗性的枯草芽孢杆菌菌株。在这些菌株中，从头合成尿苷酸的所有六种酶的相对含量在去阻遏10倍范围内保持恒定比例，这表明这些酶的合成受到协调调控。
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