鼠伤寒沙门氏菌中与pyrH相同的pyrR：pyr基因表达的调控
pyrR identical to pyrH in Salmonella typhimurium: control of expression of the pyr genes.
作者信息
Justesen J, Neuhard J
出版信息
J Bacteriol. 1975 Sep;123(3):851-4. doi: 10.1128/jb.123.3.851-854.1975.
Abstract
Mutants of Salmonella typhimurium showing constitutive synthesis of the pyrimidine biosynthetic enzymes coded for by the pyrA-F genes (G. A. O'Donavan and J. C. Gerhart, 1972) have been reinvestigated. The high rate of expression of the pyrB-F genes in these mutants as well as their pyrimidine excretion is shown to be due to mutations in the gene pyrH encoding uridine 5'-monophosphate kinase. Thus, the term pyrR used for these mutants should be replaced by the designation pyrH.
摘要
鼠伤寒沙门氏菌的突变体，其组成型合成由pyrA - F基因编码的嘧啶生物合成酶（G. A. 奥多诺万和J. C. 格哈特，1972年），已被重新研究。这些突变体中pyrB - F基因的高表达率及其嘧啶排泄被证明是由于编码尿苷5'-单磷酸激酶的pyrH基因突变所致。因此，用于这些突变体的术语pyrR应被pyrH所取代。
相似文献
1
pyrR identical to pyrH in Salmonella typhimurium: control of expression of the pyr genes.鼠伤寒沙门氏菌中与pyrH相同的pyrR：pyr基因表达的调控
J Bacteriol. 1975 Sep;123(3):851-4. doi: 10.1128/jb.123.3.851-854.1975.
2
Repression and derepression of the enzymes of the pyrimidine biosynthetic pathway in Salmonella typhimurium.鼠伤寒沙门氏菌中嘧啶生物合成途径中酶的阻遏与去阻遏
J Gen Microbiol. 1980 Nov;121(1):27-38. doi: 10.1099/00221287-121-1-27.
3
Control of expression of the pyr genes in Salmonella typhimurium: effects of variations in uridine and cytidine nucleotide pools.鼠伤寒沙门氏菌中pyr基因表达的调控：尿苷和胞苷核苷酸库变化的影响。
J Bacteriol. 1975 Mar;121(3):814-22. doi: 10.1128/jb.121.3.814-822.1975.
4
Specific repression of phosphoribosylpyrophosphate synthetase by uridine compounds in Salmonella typhimurium.鼠伤寒沙门氏菌中尿苷化合物对磷酸核糖焦磷酸合成酶的特异性抑制作用。
J Bacteriol. 1972 Apr;110(1):450-1. doi: 10.1128/jb.110.1.450-451.1972.
5
Cold-sensitive mutants of Salmonella typhimurium defective in uridine monophosphate kinase (pyrH).鼠伤寒沙门氏菌中尿苷单磷酸激酶（pyrH）缺陷的冷敏感突变体。
J Biol Chem. 1972 Oct 10;247(19):6259-65.
6
Repression of enzyme synthesis of the pyrimidine pathway in Salmonella typhimurium.鼠伤寒沙门氏菌中嘧啶途径酶合成的抑制作用
J Bacteriol. 1973 Sep;115(3):1071-6. doi: 10.1128/jb.115.3.1071-1076.1973.
7
Cold-sensitive mutant of Salmonella typhimurium defective in nucleosidediphosphokinase.鼠伤寒沙门氏菌核苷二磷酸激酶缺陷的冷敏感突变体。
J Bacteriol. 1974 Jun;118(3):1020-6. doi: 10.1128/jb.118.3.1020-1026.1974.
8
5-Fluoroorotate-resistant mutants of Salmonella typhimurium.
Can J Microbiol. 1978 Nov;24(11):1339-45. doi: 10.1139/m78-216.
9
Isolation and partial characterization of an argR mutant of Salmonella typhimurium.鼠伤寒沙门氏菌argR突变体的分离与部分特性分析。
J Bacteriol. 1976 Nov;128(2):528-35. doi: 10.1128/jb.128.2.528-535.1976.
10
Isolation and partial characterization of regulatory mutants of the pyrimidine pathway in Salmonella typhimurium.鼠伤寒沙门氏菌嘧啶途径调控突变体的分离与部分特性分析。
J Bacteriol. 1972 Mar;109(3):1085-96. doi: 10.1128/jb.109.3.1085-1096.1972.
引用本文的文献
1
Regulation of pyrimidine biosynthetic gene expression in bacteria: repression without repressors.细菌中嘧啶生物合成基因表达的调控：无阻遏物的阻遏作用
Microbiol Mol Biol Rev. 2008 Jun;72(2):266-300, table of contents. doi: 10.1128/MMBR.00001-08.
2
Nucleotide pool-sensitive selection of the transcriptional start site in vivo at the Salmonella typhimurium pyrC and pyrD promoters.鼠伤寒沙门氏菌pyrC和pyrD启动子在体内转录起始位点的核苷酸库敏感性选择
J Bacteriol. 1993 Jul;175(13):4137-44. doi: 10.1128/jb.175.13.4137-4144.1993.
3
Functions of the gene products of Escherichia coli.大肠杆菌基因产物的功能。
Microbiol Rev. 1993 Dec;57(4):862-952. doi: 10.1128/mr.57.4.862-952.1993.
4
Genes encoding Escherichia coli aspartate transcarbamoylase: the pyrB-pyrI operon.编码大肠杆菌天冬氨酸转氨甲酰酶的基因：pyrB-pyrI操纵子。
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4020-4. doi: 10.1073/pnas.79.13.4020.
5
A regulatory gene (use) affecting the expression of pyrA and certain other pyrimidine genes.一个影响pyrA及某些其他嘧啶基因表达的调控基因（用途）。
J Bacteriol. 1982 Jul;151(1):144-52. doi: 10.1128/jb.151.1.144-152.1982.
6
Repression of cytosine deaminase by pyrimidines in Salmonella typhimurium.鼠伤寒沙门氏菌中嘧啶对胞嘧啶脱氨酶的抑制作用。
J Bacteriol. 1982 Mar;149(3):1171-4. doi: 10.1128/jb.149.3.1171-1174.1982.
7
pryB mutations as suppressors of arginine auxotrophy in Salmonella typhimurium.鼠伤寒沙门氏菌中作为精氨酸营养缺陷型抑制子的pryB突变
J Bacteriol. 1980 Jan;141(1):33-40. doi: 10.1128/jb.141.1.33-40.1980.
8
Salmonella typhimurium mutants with altered expression of the pyrA gene due to changes in RNA polymerase.由于RNA聚合酶发生变化而导致pyrA基因表达改变的鼠伤寒沙门氏菌突变体。
EMBO J. 1982;1(9):1141-5. doi: 10.1002/j.1460-2075.1982.tb01309.x.
9
RNA polymerase involvement in the regulation of expression of Salmonella typhimurium pyr genes. Isolation and characterization of a fluorouracil-resistant mutant with high, constitutive expression of the pyrB and pyrE genes due to a mutation in rpoBC.RNA聚合酶参与鼠伤寒沙门氏菌pyr基因表达的调控。由于rpoBC发生突变，分离并鉴定了一株对氟尿嘧啶耐药的突变体，该突变体中pyrB和pyrE基因呈高组成型表达。
EMBO J. 1982;1(1):69-74. doi: 10.1002/j.1460-2075.1982.tb01126.x.
10
Location of amino acid alterations in mutants of aspartate transcarbamoylase: Structural aspects of interallelic complementation.天冬氨酸转氨甲酰酶突变体中氨基酸改变的位置：等位基因间互补的结构方面
Proc Natl Acad Sci U S A. 1984 Jan;81(1):115-9. doi: 10.1073/pnas.81.1.115.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Coordination of the synthesis of the enzymes in the pyrimidine pathway of E. coli.大肠杆菌嘧啶途径中酶合成的协调。
J Mol Biol. 1962 Dec;5:618-34. doi: 10.1016/s0022-2836(62)80090-4.
3
The enzymology of control by feedback inhibition.反馈抑制控制的酶学
J Biol Chem. 1962 Mar;237:891-6.
4
Control by uracil of formation of enzymes required for orotate synthesis.尿嘧啶对乳清酸合成所需酶形成的调控。
J Biol Chem. 1957 Aug;227(2):677-92.
5
Synthesis and breakdown of messenger RNA without protein synthesis.信使核糖核酸的合成与分解，无需蛋白质合成。
J Mol Biol. 1966 Feb;15(2):428-34. doi: 10.1016/s0022-2836(66)80118-3.
6
Turnover of the deoxyribonucleoside triphosphates in Escherichia coli 15 T during thymine starvation.胸腺嘧啶饥饿期间大肠杆菌15T中脱氧核糖核苷三磷酸的周转情况
Eur J Biochem. 1971 May 11;20(1):36-43. doi: 10.1111/j.1432-1033.1971.tb01359.x.
7
Pyrimidine metabolism in microorganisms.微生物中的嘧啶代谢
Bacteriol Rev. 1970 Sep;34(3):278-343. doi: 10.1128/br.34.3.278-343.1970.
8
Control of carbamyl phosphate synthesis in Salmonella typhimurium.鼠伤寒沙门氏菌中氨甲酰磷酸合成的调控
J Biol Chem. 1969 Aug 10;244(15):4033-8.
9
Repression of enzyme synthesis of the pyrimidine pathway in Salmonella typhimurium.鼠伤寒沙门氏菌中嘧啶途径酶合成的抑制作用
J Bacteriol. 1973 Sep;115(3):1071-6. doi: 10.1128/jb.115.3.1071-1076.1973.
10
Cold-sensitive mutants of Salmonella typhimurium defective in uridine monophosphate kinase (pyrH).鼠伤寒沙门氏菌中尿苷单磷酸激酶（pyrH）缺陷的冷敏感突变体。
J Biol Chem. 1972 Oct 10;247(19):6259-65.
Zotero 插件