各种治疗对吸入偏二氯乙烯毒性的影响。
Effect of various treatments on toxicity of inhaled vinylidene chloride.
作者信息
Short R D, Winston J M, Minor J L, Seifter J, Lee C C
出版信息
Environ Health Perspect. 1977 Dec;21:125-9. doi: 10.1289/ehp.7721125.
Abstract
The toxicity of vinylidene chloride (VDC) was studied in mice and rats exposed to various concentrations of the vapors for 23 hr/day. In addition, the ability of various treatments to alter parameters of toxicity was evaluated. Mice were more sensitive than rats both to the acute lethal and hepatotoxic effects of VDC. Disulfiram treatment reduced the acute lethal and hepatotoxic effects of inhaled VDC and reduced the levels of covalent bound radioactivity in the liver and kidney after the intraperitoneal administration of 14C-VDC. Treatment with diethyldithiocarbamate and thiram also protected mice from the acute lethal effects of VDC.
摘要
研究了偏二氯乙烯（VDC）对每天暴露于不同浓度蒸汽中23小时的小鼠和大鼠的毒性。此外，还评估了各种处理改变毒性参数的能力。小鼠对VDC的急性致死和肝毒性作用比大鼠更敏感。双硫仑处理降低了吸入VDC的急性致死和肝毒性作用，并降低了腹腔注射14C-VDC后肝脏和肾脏中共价结合放射性的水平。用二乙基二硫代氨基甲酸盐和福美双处理也可保护小鼠免受VDC的急性致死作用。
相似文献
1
Effect of various treatments on toxicity of inhaled vinylidene chloride.各种治疗对吸入偏二氯乙烯毒性的影响。
Environ Health Perspect. 1977 Dec;21:125-9. doi: 10.1289/ehp.7721125.
2
Toxicity of vinylidene chloride in mice and rats and its alterations by various treatments.
J Toxicol Environ Health. 1977 Dec;3(5-6):913-21. doi: 10.1080/15287397709529625.
3
Inhalation toxicity of vinyl chloride and vinylidene chloride.氯乙烯和偏二氯乙烯的吸入毒性。
Environ Health Perspect. 1977 Dec;21:25-32. doi: 10.1289/ehp.772125.
4
Influence of alcohol, dithiocarb and (+)-catechin on the hepatotoxicity and metabolism of vinylidene chloride in rats.
J Appl Toxicol. 1983 Apr;3(2):90-5. doi: 10.1002/jat.2550030208.
5
Vinylidene chloride: changes in drug-metabolizing enzymes, mutagenicity and relation to its targets for carcinogenesis.偏二氯乙烯：药物代谢酶的变化、致突变性及其与致癌靶点的关系。
Carcinogenesis. 1983 Aug;4(8):1031-8. doi: 10.1093/carcin/4.8.1031.
6
Effects of dithiocarb and (+)-cyanidanol-3 on the hepatotoxicity and metabolism of vinylidene chloride in rats.二硫代氨基甲酸盐和（+）-氰基矢车菊素-3对大鼠偏二氯乙烯肝毒性及代谢的影响。
Toxicology. 1979 Dec;15(1):55-64. doi: 10.1016/0300-483x(79)90019-2.
7
Interim results of two-year toxicological studies in rats of vinylidene chloride incorporated in the drinking water or administered by repeated inhalation.二氯乙烯掺入饮用水或通过反复吸入给予大鼠的两年毒理学研究中期结果。
Environ Health Perspect. 1977 Dec;21:33-43. doi: 10.1289/ehp.772133.
8
Pharmacokinetics of vinylidene chloride in the rat.大鼠体内偏二氯乙烯的药代动力学
Environ Health Perspect. 1977 Dec;21:99-105. doi: 10.1289/ehp.772199.
9
Carcinogenicity studies on vinylidene chloride.偏二氯乙烯的致癌性研究。
Environ Health Perspect. 1977 Dec;21:45-7. doi: 10.1289/ehp.772145.
10
Interactive toxicity and stress protein expression by vinylidene chloride and monochloroacetate in precision-cut rat liver slices.偏二氯乙烯和一氯乙酸在精密切割大鼠肝切片中的交互毒性及应激蛋白表达
Environ Health Perspect. 1998 Dec;106 Suppl 6(Suppl 6):1319-23. doi: 10.1289/ehp.98106s61319.
引用本文的文献
1
A review: trichloroethylene metabolites: potential cardiac teratogens.综述：三氯乙烯代谢物：潜在的心脏致畸剂。
Environ Health Perspect. 1998 Aug;106 Suppl 4(Suppl 4):995-9. doi: 10.1289/ehp.98106s4995.
2
Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.啮齿动物或人类肝脏组织产生的卤代乙烯、氯丁二烯和二氯丁烯的诱变和烷基化代谢产物。细胞色素P450相关微粒体单加氧酶形成环氧乙烷的证据。
Arch Toxicol. 1979 Feb 23;41(4):249-77. doi: 10.1007/BF00296896.
本文引用的文献
1
A method for rapid graphic solution of time-per cent effect curves.一种快速绘制时间-效应百分比曲线的图形求解方法。
J Pharmacol Exp Ther. 1949 Dec;97(4):399-408, 3 tab.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
METABOLISM OF DISULFIRAM AND DIETHYLDITHIOCARBAMATE IN RATS WITH DEMONSTRATION OF AN IN VIVO ETHANOL-INDUCED INHIBITION OF THE GLUCURONIC ACID CONJUGATION OF THE THIOL.双硫仑和二乙基二硫代氨基甲酸盐在大鼠体内的代谢，并证明乙醇在体内对硫醇葡萄糖醛酸结合的抑制作用。
Biochem Pharmacol. 1965 Apr;14:393-410. doi: 10.1016/0006-2952(65)90213-3.
4
5
Revised spectrophotometric methods for the determination of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, and lactic acid dehydrogenase.用于测定谷草转氨酶、谷丙转氨酶和乳酸脱氢酶的改良分光光度法。
Am J Clin Pathol. 1960 Oct;34:381-98. doi: 10.1093/ajcp/34.4_ts.381.
6
Enzyme induction and inhibition in studies on the pharmacological actions of acetophenetidin.
J Pharmacol Exp Ther. 1966 Jan;151(1):133-8.
7
The effect of cobalt chloride administration on the synthesis of hepatic microsomal cytochrome P-450.氯化钴给药对肝微粒体细胞色素P-450合成的影响。
Biochem Biophys Res Commun. 1971 Feb 19;42(4):589-95. doi: 10.1016/0006-291x(71)90528-6.
8
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.用埃尔曼试剂测定组织中的总巯基、蛋白结合巯基和非蛋白巯基。
Anal Biochem. 1968 Oct 24;25(1):192-205. doi: 10.1016/0003-2697(68)90092-4.
9
Effects on experimental animals of long-term inhalation of trichloroethylene, carbon tetrachloride, 1,1,1-trichloroethane, dichlorodifluoromethane, and 1,1-dichloroethylene.长期吸入三氯乙烯、四氯化碳、1,1,1-三氯乙烷、二氯二氟甲烷和1,1-二氯乙烯对实验动物的影响。
Toxicol Appl Pharmacol. 1967 Mar;10(2):270-89. doi: 10.1016/0041-008x(67)90110-x.
10
Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by several sulfur-containing compounds.几种含硫化合物对多环烃致癌和毒性作用的抑制
J Natl Cancer Inst. 1974 May;52(5):1583-7. doi: 10.1093/jnci/52.5.1583.
Zotero 插件