Leclerc M, Redziniak G, Panijel J, El Lababidi M
Dev Comp Immunol. 1977 Oct;1(4):299-310. doi: 10.1016/s0145-305x(77)80013-x.
Starfish axial organ cell suspensions injected subcutaneously into irradiated mice induce a characteristic angiogenesis reaction. The size of the reaction appears to be dependent upon the number of injected starfish cells. Axial organ cells also provoke a splenomegaly positive test in 16 day old chick embryos. No significant angiogenesis nor splenomegaly were induced by heat killed axial organ cells, ovocytes or branchial digestive organ cells. These results support our hypothesis that echinoid axial organ represents an ancestral primary lymphoid organ.
将海星轴器官细胞悬液皮下注射到受辐照小鼠体内会诱导出一种特征性的血管生成反应。反应的大小似乎取决于注射的海星细胞数量。轴器官细胞在16日龄鸡胚中也会引发脾肿大阳性试验。热灭活的轴器官细胞、卵母细胞或鳃消化器官细胞不会诱导出明显的血管生成或脾肿大。这些结果支持了我们的假设，即棘皮动物轴器官代表一种原始的初级淋巴器官。
