鲁氏海星（海星纲——棘皮动物）轴器官细胞的自发和诱导细胞毒性

Spontaneous and induced cytotoxicity of axial organ cells from Asterias rubens (Asterid--echinoderm).

作者信息

Luquet G, Leclerc M

出版信息

Immunol Lett. 1983 Jun;6(6):339-42. doi: 10.1016/0165-2478(83)90078-0.

Abstract

Spontaneously occurring cytotoxicity of starfish axial organ cells on target cells has been studied. It appears that in an allogeneic system no cytotoxic phenomenon occurs after 4 or 6 h of culture, whereas spontaneous cytotoxicity toward malignant vertebrate target cells is shown and reaches its maximum at 37 degrees C. In a certain way, the axial organ cell population includes cells, which may be compared with vertebrate natural killer cells. On the other hand, it must also be noted that axial organ cells are able to exert in a few cases, an induced cytotoxicity on MBL2 cells. This phenomenon appears at the end of the fourth day of culture.

摘要

已经对海星轴器官细胞对靶细胞的自发细胞毒性进行了研究。结果表明，在同种异体系统中，培养4或6小时后未出现细胞毒性现象，而对恶性脊椎动物靶细胞表现出自发细胞毒性，并在37℃时达到最大值。在某种程度上，轴器官细胞群体包括一些细胞，这些细胞可与脊椎动物的自然杀伤细胞相比较。另一方面，还必须指出的是，轴器官细胞在少数情况下能够对MBL2细胞产生诱导细胞毒性。这种现象出现在培养的第四天结束时。