Ludwig P W, Hunninghake D B, Hoidal J R
Lancet. 1982 Aug 14;2(8294):348-50. doi: 10.1016/s0140-6736(82)90546-3.
Polymorphonuclear leucocytes (PMN) from a group of subjects with hyperlipoproteinaemia (HLP) had higher oxidative metabolism with greater release of superoxide anion (O2-) than PMN from age-matched controls. Release of O2- was significantly correlated with serum cholesterol and light-density-lipoprotein-cholesterol levels, PMN from HLP subjects also has higher hexose monophosphate shunt activity and chemiluminescence than controls. A causal relation was suggested by the finding that oxidative metabolism was normal in a group of HLP subjects whose lipid levels were lowered by treatment with cholestyramine.
与年龄匹配的对照组相比，一组高脂血症（HLP）患者的多形核白细胞（PMN）具有更高的氧化代谢水平，超氧阴离子（O2-）释放量更大。O2-的释放与血清胆固醇和低密度脂蛋白胆固醇水平显著相关，HLP患者的PMN的磷酸己糖旁路活性和化学发光也高于对照组。一组通过消胆胺治疗使血脂水平降低的HLP患者氧化代谢正常，这一发现提示了其间的因果关系。
