脐血多形核白细胞中的氧化代谢
Oxidative metabolism in cord-blood polymorphonuclear leucocytes.
作者信息
Strauss R G, Seifert M J
出版信息
Arch Dis Child. 1978 Jan;53(1):78-80. doi: 10.1136/adc.53.1.78.
Polymorphonuclear leucocytes were isolated from cord-blood samples collected from healthy, term infants. Oxidative metabolism was assessed in these cells by hexose monophosphate shunt activity and chemiluminescence. Basal levels of oxidative metabolism were spontaneously increased in resting (nonphagocytic) cord-blood cells as compared to adult controls. As a response to phagocytosis, cord-blood cells initiated the expected increase in oxidative metabolism and reached normal peak values of activity. However, these cells were unable to maintain the high metabolic rate for as long a time as adult controls. This aberration of leucocyte function may indicate a deficiency of metabolic reserve and could be related to the increased susceptibility of newborns to bacterial infections.
从健康足月婴儿采集的脐带血样本中分离出多形核白细胞。通过磷酸己糖旁路活性和化学发光评估这些细胞中的氧化代谢。与成人对照组相比，静息（非吞噬性）脐带血细胞中氧化代谢的基础水平自发升高。作为对吞噬作用的反应，脐带血细胞启动了氧化代谢预期的增加，并达到了正常的活性峰值。然而，这些细胞无法像成人对照组那样长时间维持高代谢率。白细胞功能的这种异常可能表明代谢储备不足，并且可能与新生儿对细菌感染的易感性增加有关。
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