丁硫氨酸亚砜胺及其高级同系物（谷胱甘肽合成的强效抑制剂）的作用机制、代谢及毒性 - Suppr

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Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

作者信息

Griffith O W

出版信息

J Biol Chem. 1982 Nov 25;257(22):13704-12.

PMID:6128339

Abstract

摘要

相似文献

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.丁硫氨酸亚砜胺及其高级同系物（谷胱甘肽合成的强效抑制剂）的作用机制、代谢及毒性

J Biol Chem. 1982 Nov 25;257(22):13704-12.

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).丁硫氨酸亚砜胺（S-正丁基高半胱氨酸亚砜胺）对谷胱甘肽合成的强效特异性抑制作用。

J Biol Chem. 1979 Aug 25;254(16):7558-60.

Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.原硫氨酸亚砜亚胺（S-正丙基高半胱氨酸亚砜亚胺）对谷胱甘肽生物合成的抑制作用，γ-谷氨酰半胱氨酸合成酶的一种选择性抑制剂。

J Biol Chem. 1979 Feb 25;254(4):1205-10.

Glutathione biosynthesis and its inhibition.谷胱甘肽的生物合成及其抑制作用。

Methods Enzymol. 1995;252:26-30. doi: 10.1016/0076-6879(95)52005-8.

Depletion of glutathione by inhibition of biosynthesis.通过抑制生物合成消耗谷胱甘肽。

Methods Enzymol. 1981;77:59-63. doi: 10.1016/s0076-6879(81)77011-3.

Buthionine sulfoximine inhibition of glutathione biosynthesis enhances hepatic lipid peroxidation in rats during acute ethanol intoxication.丁硫氨酸亚砜亚胺对谷胱甘肽生物合成的抑制作用会增强急性乙醇中毒大鼠的肝脏脂质过氧化。

Alcohol Alcohol. 1989;24(6):519-24. doi: 10.1093/oxfordjournals.alcalc.a044954.

Analytical and preparative separation of the diastereomers of L-buthionine (SR)-sulfoximine, a potent inhibitor of glutathione biosynthesis.L-丁硫氨酸（SR）-亚砜亚胺的非对映异构体的分析和制备分离，谷胱甘肽生物合成的有效抑制剂。

Anal Biochem. 1991 May 1;194(2):268-77. doi: 10.1016/0003-2697(91)90229-m.

Differential inhibition of glutamine and gamma-glutamylcysteine synthetases by alpha-alkyl analogs of methionine sulfoximine that induce convulsions.可诱发惊厥的蛋氨酸亚砜亚胺α-烷基类似物对谷氨酰胺和γ-谷氨酰半胱氨酸合成酶的差异性抑制作用。

J Biol Chem. 1978 Apr 10;253(7):2333-8.

Depletion of glutathione selectively inhibits synthesis of leukotriene C by macrophages.谷胱甘肽的耗尽选择性地抑制巨噬细胞对白三烯C的合成。

Proc Natl Acad Sci U S A. 1981 Apr;78(4):2532-6. doi: 10.1073/pnas.78.4.2532.

Effects of methionine sulfoximine analogs on the synthesis of glutamine and glutathione: possible chemotherapeutic implications.蛋氨酸亚砜亚胺类似物对谷氨酰胺和谷胱甘肽合成的影响：可能的化疗意义。

Cancer Treat Rep. 1979 Jun;63(6):1115-21.

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Pervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds.宿主和病毒蛋白对半胱氨酸反应性亲电化合物的广泛聚集和耗竭。

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