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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Sakata T, von Engelhardt W

Comp Biochem Physiol A Comp Physiol. 1983;74(2):459-62. doi: 10.1016/0300-9629(83)90631-x.

Short chain fatty acids [SCFA: acetate 75, propionate 35, butyrate 20 (microM)] introduced intraluminally into the colon increased the mitotic index and the labeling index of the large intestinal epithelial cells within 60 min in fasted rats. 2. Epithelia that lacked direct contact with SCFA were also stimulated. 3. SCFA did not have such a stimulatory effect either in vagotomized rats or in sympathectomized rats. 4. These results suggest that SCFA stimulate epithelial cell proliferation in the large intestine of fasted rats via the autonomic nervous system.

向禁食大鼠的结肠腔内注入短链脂肪酸[SCFA：乙酸盐75、丙酸盐35、丁酸盐20（微摩尔）]，在60分钟内可提高大肠上皮细胞的有丝分裂指数和标记指数。2. 未与SCFA直接接触的上皮细胞也受到了刺激。3. SCFA在迷走神经切断的大鼠或交感神经切除的大鼠中均未产生这种刺激作用。4. 这些结果表明，SCFA通过自主神经系统刺激禁食大鼠大肠中的上皮细胞增殖。

Sakata T, von Engelhardt W

Comp Biochem Physiol A Comp Physiol. 1983;74(2):459-62. doi: 10.1016/0300-9629(83)90631-x.

Short chain fatty acids [SCFA: acetate 75, propionate 35, butyrate 20 (microM)] introduced intraluminally into the colon increased the mitotic index and the labeling index of the large intestinal epithelial cells within 60 min in fasted rats. 2. Epithelia that lacked direct contact with SCFA were also stimulated. 3. SCFA did not have such a stimulatory effect either in vagotomized rats or in sympathectomized rats. 4. These results suggest that SCFA stimulate epithelial cell proliferation in the large intestine of fasted rats via the autonomic nervous system.

向禁食大鼠的结肠腔内注入短链脂肪酸[SCFA：乙酸盐75、丙酸盐35、丁酸盐20（微摩尔）]，在60分钟内可提高大肠上皮细胞的有丝分裂指数和标记指数。2. 未与SCFA直接接触的上皮细胞也受到了刺激。3. SCFA在迷走神经切断的大鼠或交感神经切除的大鼠中均未产生这种刺激作用。4. 这些结果表明，SCFA通过自主神经系统刺激禁食大鼠大肠中的上皮细胞增殖。