• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

炎症性肠病和结直肠癌发生中肠道干细胞的营养基因组学基础

Nutrigenomic underpinnings of intestinal stem cells in inflammatory bowel disease and colorectal cancer development.

作者信息

Ho Jennifer, Puoplo Nicholas, Pokharel Namrata, Hirdaramani Aanya, Hanyaloglu Aylin C, Cheng Chia-Wei

机构信息

Institute of Human Nutrition, Columbia University Irving Medical Center, New York City, NY, United States.

Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York City, NY, United States.

出版信息

Front Genet. 2024 Aug 30;15:1349717. doi: 10.3389/fgene.2024.1349717. eCollection 2024.

DOI:10.3389/fgene.2024.1349717
PMID:39280096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11393785/
Abstract

Food-gene interaction has been identified as a leading risk factor for inflammatory bowel disease (IBD) and colorectal cancer (CRC). Accordingly, nutrigenomics emerges as a new approach to identify biomarkers and therapeutic targets for these two strongly associated gastrointestinal diseases. Recent studies in stem cell biology have further shown that diet and nutrition signal to intestinal stem cells (ISC) by altering nutrient-sensing transcriptional activities, thereby influencing barrier integrity and susceptibility to inflammation and tumorigenesis. This review recognizes the dietary factors related to both CRC and IBD and investigates their impact on the overlapping transcription factors governing stem cell activities in homeostasis and post-injury responses. Our objective is to provide a framework to study the food-gene regulatory network of disease-contributing cells and inspire new nutrigenomic approaches for detecting and treating diet-related IBD and CRC.

摘要

食物-基因相互作用已被确定为炎症性肠病（IBD）和结直肠癌（CRC）的主要危险因素。因此，营养基因组学作为一种新方法出现，用于识别这两种密切相关的胃肠道疾病的生物标志物和治疗靶点。干细胞生物学的最新研究进一步表明，饮食和营养通过改变营养感应转录活性向肠道干细胞（ISC）发出信号，从而影响屏障完整性以及对炎症和肿瘤发生的易感性。本综述识别了与CRC和IBD相关的饮食因素，并研究了它们对在体内平衡和损伤后反应中控制干细胞活动的重叠转录因子的影响。我们的目标是提供一个框架，以研究促成疾病的细胞的食物-基因调控网络，并激发新的营养基因组学方法来检测和治疗与饮食相关的IBD和CRC。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d6d/11393785/40bf79b8f9e9/fgene-15-1349717-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d6d/11393785/1430b605df58/fgene-15-1349717-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d6d/11393785/6f1441c43697/fgene-15-1349717-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d6d/11393785/42efd599593a/fgene-15-1349717-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d6d/11393785/40bf79b8f9e9/fgene-15-1349717-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d6d/11393785/1430b605df58/fgene-15-1349717-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d6d/11393785/6f1441c43697/fgene-15-1349717-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d6d/11393785/42efd599593a/fgene-15-1349717-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d6d/11393785/40bf79b8f9e9/fgene-15-1349717-g004.jpg

相似文献

1
Nutrigenomic underpinnings of intestinal stem cells in inflammatory bowel disease and colorectal cancer development.炎症性肠病和结直肠癌发生中肠道干细胞的营养基因组学基础
Front Genet. 2024 Aug 30;15:1349717. doi: 10.3389/fgene.2024.1349717. eCollection 2024.
2
Possible role of nutrition in the prevention of inflammatory bowel disease-related colorectal cancer: A focus on human studies.营养在预防炎症性肠病相关结直肠癌中的可能作用：以人类研究为重点。
Nutrition. 2023 Jun;110:111980. doi: 10.1016/j.nut.2023.111980. Epub 2023 Feb 3.
3
A Personalised Dietary Approach-A Way Forward to Manage Nutrient Deficiency, Effects of the Western Diet, and Food Intolerances in Inflammatory Bowel Disease.个性化饮食方法——管理炎症性肠病中营养素缺乏、西方饮食影响和食物不耐受的新途径。
Nutrients. 2019 Jul 5;11(7):1532. doi: 10.3390/nu11071532.
4
Dietary Factors in the Control of Gut Homeostasis, Intestinal Stem Cells, and Colorectal Cancer.膳食因素在肠道内稳态、肠干细胞和结直肠癌控制中的作用。
Nutrients. 2019 Dec 3;11(12):2936. doi: 10.3390/nu11122936.
5
Nutrigenomics and nutrigenetics in inflammatory bowel diseases.营养基因组学与炎症性肠病中的营养遗传学。
J Clin Gastroenterol. 2012 Oct;46(9):735-47. doi: 10.1097/MCG.0b013e31825ca21a.
6
AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert Review.AGA 临床实践更新：炎症性肠病患者的饮食和营养治疗：专家综述。
Gastroenterology. 2024 Mar;166(3):521-532. doi: 10.1053/j.gastro.2023.11.303. Epub 2024 Jan 23.
7
Nutrigenomics and inflammatory bowel diseases.营养基因组学与炎症性肠病
Expert Rev Clin Immunol. 2010 Jul;6(4):573-83. doi: 10.1586/eci.10.43.
8
Inflammatory bowel disease-related colorectal cancer: Past, present and future perspectives.炎症性肠病相关结直肠癌：过去、现在与未来展望
World J Gastrointest Oncol. 2022 Mar 15;14(3):547-567. doi: 10.4251/wjgo.v14.i3.547.
9
Nutrigenomics and gut health.营养基因组学与肠道健康。
Mutat Res. 2007 Sep 1;622(1-2):1-6. doi: 10.1016/j.mrfmmm.2007.05.001. Epub 2007 May 5.
10
TRIENNIAL LACTATION SYMPOSIUM: Nutrigenomics in dairy cows: Nutrients, transcription factors, and techniques.三年一度的泌乳研讨会：奶牛营养基因组学——营养物质、转录因子与技术
J Anim Sci. 2015 Dec;93(12):5531-53. doi: 10.2527/jas.2015-9192.

引用本文的文献

1
Prognosis in stage II colon cancer: Expanding the horizons of risk factors.II期结肠癌的预后：拓展风险因素的视野
World J Gastrointest Oncol. 2025 Feb 15;17(2):100552. doi: 10.4251/wjgo.v17.i2.100552.

本文引用的文献

1
Probiotic Consortia Protect the Intestine Against Radiation Injury by Improving Intestinal Epithelial Homeostasis.益生菌联合物通过改善肠道上皮稳态来保护肠道免受辐射损伤。
Int J Radiat Oncol Biol Phys. 2024 Sep 1;120(1):189-204. doi: 10.1016/j.ijrobp.2024.03.003. Epub 2024 Mar 12.
2
Nutrient metabolism in regulating intestinal stem cell homeostasis.营养代谢在调节肠道干细胞稳态中的作用。
Cell Prolif. 2024 Jun;57(6):e13602. doi: 10.1111/cpr.13602. Epub 2024 Feb 22.
3
The Genetics of Inflammatory Bowel Disease.炎症性肠病的遗传学。
Mol Diagn Ther. 2024 Jan;28(1):27-35. doi: 10.1007/s40291-023-00678-7. Epub 2023 Oct 17.
4
Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer.美沙拉嗪的抗肿瘤作用机制及其在结直肠癌预防中的潜在作用。
Molecules. 2023 Jun 29;28(13):5081. doi: 10.3390/molecules28135081.
5
A Roadmap for the Human Gut Cell Atlas.人类肠道细胞图谱研究路线图
Nat Rev Gastroenterol Hepatol. 2023 Sep;20(9):597-614. doi: 10.1038/s41575-023-00784-1. Epub 2023 May 31.
6
Inflammation-Driven Colorectal Cancer Associated with Colitis: From Pathogenesis to Changing Therapy.炎症驱动的与结肠炎相关的结直肠癌：从发病机制到治疗变革
Cancers (Basel). 2023 Apr 20;15(8):2389. doi: 10.3390/cancers15082389.
7
Excess Dietary Sugar Alters Colonocyte Metabolism and Impairs the Proliferative Response to Damage.过量的膳食糖会改变结肠细胞的代谢，并损害对损伤的增殖反应。
Cell Mol Gastroenterol Hepatol. 2023;16(2):287-316. doi: 10.1016/j.jcmgh.2023.05.001. Epub 2023 May 11.
8
Inulin diet uncovers complex diet-microbiota-immune cell interactions remodeling the gut epithelium.菊粉饮食揭示了复杂的饮食-微生物群-免疫细胞相互作用，重塑肠道上皮。
Microbiome. 2023 Apr 26;11(1):90. doi: 10.1186/s40168-023-01520-2.
9
Possible role of nutrition in the prevention of inflammatory bowel disease-related colorectal cancer: A focus on human studies.营养在预防炎症性肠病相关结直肠癌中的可能作用：以人类研究为重点。
Nutrition. 2023 Jun;110:111980. doi: 10.1016/j.nut.2023.111980. Epub 2023 Feb 3.
10
Serum vitamin D concentration, vitamin D-related polymorphisms, and colorectal cancer risk.血清维生素 D 浓度、维生素 D 相关多态性与结直肠癌风险。
Int J Cancer. 2023 Jul 15;153(2):278-289. doi: 10.1002/ijc.34521. Epub 2023 Mar 29.