Cordes U, Rothmund M, Eberle S, Krause U, Kolbe K, Braun B, Reinsdorf S, Beyer J
Dtsch Med Wochenschr. 1983 Mar 25;108(12):462-4. doi: 10.1055/s-2008-1069579.
Plasma levels of calcitonin and carcinoembryonic antigen (CEA) were determined pre-operatively and two months postoperatively in ten patients with C-cell carcinoma as part of multiple endocrine neoplasia type II. In addition, CEA was measured in extracts from 20 different phaeochromocytomas (five from patients with multiple endocrine neoplasia type II, 15 from patients with sporadic phaeochromocytoma). In comparison, CEA concentration was determined in extracts from five C-cell carcinomas of patients with multiple endocrine neoplasia type II. When correlating pre- and postoperative calcitonin and CEA levels, there was a significant linear relationship (P less than 0.001). CEA concentration in extracts from phaeochromocytomas was at the lower level of sensitivity (4.7 +/- 12.2 pg/mg tumour wet-weight). In extracts from C-cell carcinomas they were much higher (6402 +/- 4570 pg/mg tumour wet-weight). The results suggest that it is possible, in patients with phaeochromocytoma and high calcitonin levels, to differentiate by additional CEA determination between C-cell carcinoma in the course of multiple endocrine neoplasia type II and sporadic phaeochromocytoma with ectopic calcitonin liberation.
作为II型多发性内分泌腺瘤病的一部分，对10例C细胞癌患者在术前和术后两个月测定了降钙素和癌胚抗原（CEA）的血浆水平。此外，还对20个不同嗜铬细胞瘤的提取物进行了CEA检测（其中5个来自II型多发性内分泌腺瘤病患者，15个来自散发性嗜铬细胞瘤患者）。作为对照，对II型多发性内分泌腺瘤病患者的5个C细胞癌的提取物进行了CEA浓度测定。在对比术前和术后的降钙素及CEA水平时，发现二者存在显著的线性关系（P<0.001）。嗜铬细胞瘤提取物中的CEA浓度处于灵敏度较低的水平（4.7±12.2 pg/mg肿瘤湿重）。而在C细胞癌提取物中，CEA浓度则高得多（6402±4570 pg/mg肿瘤湿重）。结果表明，对于嗜铬细胞瘤且降钙素水平较高的患者，通过额外测定CEA，有可能区分II型多发性内分泌腺瘤病病程中的C细胞癌和伴有异位降钙素释放的散发性嗜铬细胞瘤。
