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生药的生物活性成分。II. “芍药甘草汤”中的抗过敏成分 芍药苷及其衍生物的抗炎特性。

Biologically active principles of crude drugs. II. Anti-allergic principles in "Shoseiryu-To" anti-inflammatory properties of paeoniflorin and its derivatives.

作者信息

Yamahara J, Yamada T, Kimura H, Sawada T, Fujimura H

出版信息

J Pharmacobiodyn. 1982 Nov;5(11):921-9. doi: 10.1248/bpb1978.5.921.

DOI:10.1248/bpb1978.5.921
PMID:6131955
Abstract

Anti-inflammatory properties of paeoniflorin and its derivatives were examined in experimental animals. Paeoniflorin, desbenzoylpaeoniflorin and new monoterpene glucoside 'paeonon' inhibited experimental contact hypersensitivities and passive cutaneous anaphylaxis reaction. Paeonon inhibited tissue swelling in the adjuvant arthritis, while paeoniflorin and its related compounds were ineffective in inhibiting non-allergic inflammatory response.

摘要

在实验动物中研究了芍药苷及其衍生物的抗炎特性。芍药苷、去苯甲酰芍药苷和新的单萜糖苷“芍药新苷”可抑制实验性接触性超敏反应和被动皮肤过敏反应。芍药新苷可抑制佐剂性关节炎中的组织肿胀，而芍药苷及其相关化合物在抑制非过敏性炎症反应方面无效。

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J Pharmacobiodyn. 1982 Nov;5(11):921-9. doi: 10.1248/bpb1978.5.921.
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[High-speed liquid chromatographic analysis of drugs. V. Rapid estimation of paeoniflorin in paeony root (author's transl)].[药物的高速液相色谱分析。V. 芍药根中芍药苷的快速测定（作者译）]
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Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-adrenergic receptor desensitization in rats with adjuvant arthritis.芍药苷通过增强佐剂性关节炎大鼠肠系膜淋巴结淋巴细胞的β2 - 肾上腺素能受体脱敏诱导免疫耐受。
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[High-speed liquid chromatographic analysis of drugs. XII. Determination of paeoniflorin in pharmaceutical preparations including paeony root (author's transl)].药物的高速液相色谱分析。十二。含芍药根的药物制剂中芍药苷的测定（作者译）
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