Lee Bomi, Shin Yong-Wook, Bae Eun-Ah, Han San-Jun, Kim Joo-Sun, Kang Sam-Sik, Kim Dong-Hyun
Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, 1 Hoegi, Dongdaemun-ku, Seoul, Korea.
Arch Pharm Res. 2008 Apr;31(4):445-50. doi: 10.1007/s12272-001-1177-6. Epub 2008 May 1.
The root of Paeonia lactiflora PALL (PL, Family Paeoniaceae) has been used frequently as an antipyretic and anti-inflammatory agent in traditional medicines of Korea, China and Japan. To evaluate antiallergic effect of PL, we isolated its main constituents, paeoniflorin and paeonol, and evaluated in vivo their inhibitory effects against passive cutaenous anaphylaxis (PCA) reaction induced by IgE-antigen complex and scratching behaviors induced by compound 48/80. PL, paeoniflorin and paeonol potently inhibited PCA reaction and scratching behaviors in mice. Paeoniflorin exhibited the most potent inhibition against scratching behaviors and the acetic acid-induced writhing syndrome in mice. Paeonol most potently inhibited PCA reaction and mast cells degranulation. These findings suggest that PL can improve IgE-induced anaphylaxis and scratching behaviors, and may be due to the effect of its constituents, paeoniflorin and paeonol.
芍药（芍药科）的根在韩国、中国和日本的传统医学中常被用作解热和抗炎剂。为了评估芍药的抗过敏作用，我们分离了其主要成分芍药苷和丹皮酚，并在体内评估了它们对IgE-抗原复合物诱导的被动皮肤过敏反应（PCA）以及化合物48/80诱导的搔抓行为的抑制作用。芍药、芍药苷和丹皮酚均能有效抑制小鼠的PCA反应和搔抓行为。芍药苷对小鼠搔抓行为和醋酸诱导的扭体反应表现出最强的抑制作用。丹皮酚对PCA反应和肥大细胞脱颗粒的抑制作用最强。这些发现表明，芍药可以改善IgE诱导的过敏反应和搔抓行为，这可能归因于其成分芍药苷和丹皮酚的作用。
