氯硝西泮用于儿童。一项比较氯硝西泮、地西泮、异丙嗪和安慰剂的双盲试验。

Lorazepam in children. A double-blind trial comparing lorazepam, diazepam, trimeprazine and placebo.

作者信息

Burtles R, Astley B

出版信息

Br J Anaesth. 1983 Apr;55(4):275-9. doi: 10.1093/bja/55.4.275.

DOI:10.1093/bja/55.4.275

Abstract

One hundred patients aged 5-13 yr were randomly allocated to four groups in a double-blind study of premedication. Drugs studied were lorazepam, diazepam and trimeprazine. A placebo group was included. All the drugs appeared satisfactory as premedicants. Lorazepam induced the most sedation immediately after surgery, but by 4 h lorazepam and diazepam appeared similar. Lorazepam produced better amnesia than the other drugs. There were no untoward side-effects and no cardiorespiratory depression in any group. Lorazepam appears a suitable premedicant for children.

摘要

在一项关于术前用药的双盲研究中，100名年龄在5至13岁的患者被随机分为四组。所研究的药物有劳拉西泮、地西泮和曲普利啶。设立了一个安慰剂组。所有药物作为术前用药似乎都令人满意。术后即刻，劳拉西泮诱导的镇静作用最强，但到4小时时，劳拉西泮和地西泮的效果相似。劳拉西泮产生的遗忘作用比其他药物更好。任何组均未出现不良副作用，也没有心肺抑制情况。劳拉西泮似乎是适合儿童的术前用药。