Hypersensitivity to mosquito bite and malignant histocytosis.

The follow-up data from 21 cases in Japan of severe local and constitutional hypersensitivity to mosquito bite (mosquito allergy) were collected. Three cases are now cured and no longer show hypersensitivity and 9 cases died, in 7 of these death being attributed to malignant histiocytosis (MH) or related conditions. In another case a systemic malignant neoplasm was suspected but was not confirmed as MH. Since both mosquito allergy and MH are exceedingly rare conditions, the association of the two is unlikely to be coincidental, and the possibility of a participation of viral infection is suspected as the cause of the systemic histiocytoses including MH.