暴露于高碳酸血症的豚鼠血液酸碱状态的调节

Arterial blood acid-base status of unanesthetized, unrestrained guinea pigs was studied during 6 hr of exposure to 4, 8, 10 and 14.5% CO2. 2. During exposure to 4% CO2, blood pH was kept within the range of control values, despite significant increase of 5-8 mmHg in PaCO2. 3. Most of the changes in blood acid-base status occurred during the first 30-60 min of exposure to CO2, and only minor changes were observed during the remaining exposure period (up to 6 hr). 4. In-vivo CO2 titration curves were not linear over the CO2 range studied here. The slope of the in-vivo H+/PaCO2 line became much more steep at PaCO2 values higher than 65-75 mmHg. 5. The apparent whole body buffer value (beta = -delta HCO-3/delta pH), being 42.6 slykes after 1 hr for the 4-10% CO2 range, changed to -18.1 slykes when calculated for 1 hr at the 10-14.5% CO2 range. 6. It is concluded that guinea pigs can regulate their blood pH better than rats, rabbits, dogs and men when exposed for short periods to CO2 levels up to 10%. 7. When exposed to higher levels (14.5%) of CO2, they show a very limited capability for regulating their blood pH--much less than rats, rabbits and dogs.

研究了未麻醉、未束缚的豚鼠在暴露于4%、8%、10%和14.5%二氧化碳环境6小时期间的动脉血酸碱状态。2. 在暴露于4%二氧化碳期间，尽管动脉血二氧化碳分压显著升高5 - 8 mmHg，但血液pH值仍保持在对照值范围内。3. 血液酸碱状态的大多数变化发生在暴露于二氧化碳的最初30 - 60分钟内，在剩余的暴露期间（长达6小时）仅观察到微小变化。4. 在此研究的二氧化碳范围内，体内二氧化碳滴定曲线不是线性的。当动脉血二氧化碳分压值高于65 - 75 mmHg时，体内氢离子/动脉血二氧化碳分压曲线的斜率变得陡峭得多。5. 表观全身缓冲值（β = -Δ碳酸氢根/ΔpH），在4% - 10%二氧化碳范围内暴露1小时后为42.6斯拉克斯，在10% - 14.5%二氧化碳范围内计算1小时时变为 - 18.1斯拉克斯。6. 得出的结论是，豚鼠在短时间暴露于高达10%的二氧化碳水平时，比大鼠、兔子、狗和人类能更好地调节其血液pH值。7. 当暴露于更高水平（14.5%）的二氧化碳时，它们调节血液pH值的能力非常有限——远低于大鼠、兔子和狗。

Regulation of blood acid-base status in guinea pigs exposed to hypercapnia.